Diagnostic Kits/Direct-to-consumer genetic testing- two sides of the coin

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Farkas and Holland. Direct-to-consumer genetic testing: two sides of the coin. The Journal of molecular diagnostics : JMD (2009) vol. 11 (4) pp. 263-5. [Accessed 14 Dec 2009: http://jmd.amjpathol.org/cgi/content/full/11/4/263]

The editorial declares:

  • that genetic counselors are essential when interpreting complex genetic health information, such as the results of DTC genomic tests.
  • Lab test results should only be generated using FDA approved / cleared tests or
  • developed and validated appropriately as a Laboratory Developed Test ("homebrew"?) performed in a CLIA lab.


References 3 New England Journal of Medicine papers about elusive genotype/phenotype correlations:

  1. Goldstein DB: Common genetic variation and human traits. N Engl J Med 2009, 360:1696-1698 Free Full Text
  2. Hirschhorn JN: Genomewide association studies — illuminating biologic pathways. N Engl J Med 2009, 360:1699-1701 Free Full Text
  3. Kraft P, Hunter DJ: Genetic risk prediction — are we there yet? N Engl J Med 2009, 360:1701-1703 Free Full Text

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