ON THE COMPLEX ECONOMICS OF PATENT SCOPE
Robert P. Merges * and Richard R. Nelson

90 Colum. L. Rev. 839

Click here to see material excised from the opinion.

II. THE ECONOMICS OF THE PATENT SYSTEM REVISITED

A. The Social Benefits and Costs of the Patent System


In most analyses of the different aspects of the patent system, concern has centered on a simple tradeoff. The analysis has concentrated on how changing patent coverage affects the balance between incentives to the inventor and underuse of the invention due to patent monopolies. Thus, Nordhaus's analysis of optimum patent life is concerned with the tradeoff between increased inventive effort resulting from longer anticipated patent life and greater deadweight costs associated with longer monopoly. n122 Kaplow uses these two variable to analyze the effects of allowing the patent holder greater freedom regarding licensing agreements. n123 Gilbert and Shapiro's recent work on optimal patent length and breadth builds on the tradeoff model, as does Klemperer's. n124

However, other analyses of the effects of the patent system open [*869] up a much more complex set of issues. These studies recognize that at any time many actors may be in the invention game, and that the game may have many rounds. This broader orientation brings into view the question of how the lure or presence of a strong patent can influence the multiactor portfolio of inventive efforts. n125 It also alerts the analyst to the possible effects of patents on the ability or desire of different parties to stay in the inventing competition over time, and on the efficiency of the inventive effort over the long run. n126

We believe that analysis of the effects of varying patent scope needs to recognize this dynamic multiactor context. One problem with the analysis of Gilbert and Shapiro, and Klemperer, is that this is not done. Both papers treat greater scope as roughly similar to greater duration in terms of its incentive effect on initial invention. n127 We have no real trouble with that. n128 Both treat the social costs of greater scope as precluding a wider range of substitutes covered by the patent. n129 Again, no real argument. However, they treat these substitutes as if they were already in existence or could be made so trivially. n130 It is [*870] is here that we find their analysis inadequate. Our concern is with the effects of patent scope decisions on whether or not, and if so how efficiently, these substitutes are created. More importantly, these papers for the most part ignore what we consider a critical set of "substitutes": subsequent inventions that not only substitute for the initial invention, but also improve on it in some way. Since some of the follow-on efforts of inventors could result in something not simply slightly different but significantly better than the patented technology, broad patents could discourage much useful research. Thus, these papers are not of much help in rationalizing and reforming those aspects of legal doctrine that apply to the economically significant class of improvement inventions.

The economic models that do try to encompass multiactor dynamics are quite stylized. In some, invention is analogized to fishing from a common pool. n131 There are many competitive inventors, and the first to make an invention gets the patent on it. Each knows that as others catch (invent) there is less in the pool for her. The result is "overfishing": too many people seeking inventions at once. n132 Other economists have modelled technical advance in terms of a multifirm "race to patent," in which many would-be inventors identify a particular goal, and the first to achieve the goal gets the patent. n133 A good deal of variation has been introduced into these models, with different assumptions being made about such variables as the strength of patents and the costs and benefits of innovating versus imitating. n134 Many of the implications of these models are sensitive to particular assumptions, but some are robust. In particular, under a wide range of assumptions rivalrous inventive efforts generate a great deal of inefficiency.

Despite the drawbacks of these models, the authors of this paper [*871] regard that basic conclusion as persuasive. Not only does proprietary control of technology tend to cause "dead weight" costs due to restrictions on use. (We presume here that in general it is not possible to write licensing agreements to completely offset this problem, a matter to which we will return shortly.) Where invention is rivalrous, the process leading to invention is itself inefficient. With exclusive property rights, we pay both kinds of costs in exchange for the benefits of technical advance. But recognition of the costs of rivalrous inventive efforts leads one to speculate about how these costs might be mitigated. This question is the source of Edmund Kitch's prospect theory.

1. The Prospect Theory. -- Edmund Kitch, in formulating his "prospect theory" of patent rights, moved beyond the static tradeoff model mentioned earlier and incorporated into his analysis some of the insights of the common pool models. Kitch analogized patents to mining claims. Like an exclusive claim to the minerals that may be produced from a plot of land, Kitch emphasized that patents are granted after invention but before commercialization. According to Kitch, this has two advantages: (1) it allows "breathing room" for the inventor to invest in development without fear that another firm will preempt her or steal her work; n135 and (2) it allows the inventor to coordinate her activities with those of potential imitators to reduce inefficient duplication of inventive effort. n136 This amounts to granting rights over an unexplored pool, with the right-holder being permitted to charge for access to various parts of the pool. n137 Thus the inefficiencies associated with rivalrous uncoordinated invention, as in the fishing or race models, can be avoided.

Kitch goes further in suggesting that the prospect theory "may clarify the process and conditions under which a monopolistic industry will be more efficient than a competitive one." n138 He states that this enhanced efficiency "turns not upon the size of the firm, but its dominance over a fruitful technological prospect." n139

Reacting to the inefficiencies highlighted by the fishing models, Kitch clearly has a preference for single-firm domination of a technological [*872] prospect. As Kitch recognizes, this can be achieved by licensing, where a number of firms hold patents on components of a key invention. Alternatively, one firm can hold a single dominant patent. In either case, the advantage seen by Kitch is that development is under the control of a single entity. Rivalry is avoided. Planning is possible.

We have trouble with the view that coordinated development is better than rivalrous. In principle it could be, but in practice it generally is not. Much of our case is empirical. But there are sound theoretical reasons for doubting the advantages of centralization.

For one thing, under rivalrous competition in invention and innovation there is a stick as well as a carrot. Block rivalry and one blocks or greatly diminishes the threatened costs of inaction. Kitch assumes a model of individual or firm behavior where if an action is profitable it will be taken, regardless of whether inaction would still allow the firm to meet its desired (but suboptimal) performance goals. Different models of behavior, like Simon's satisficing hypothesis, predict otherwise. n140 As we shall see, there are many instances when a firm that thought it had control over a broad technology rested on its laurels until jogged to action by an outside threat. n141

[*873] More generally, the model of behavior Kitch is employing ignores the limits on cognitive capacity and the tendency to focus on past experience that are characteristics of other models and of organizational behavior as we know it. n142 Once a firm develops and becomes competent in one part of a "prospect," it may be very hard for it to give much attention to other parts, even though in the eyes of others, there may be great promise there. n143 Again, our empirical explorations show many examples of this. Consequently, one might expect that many independent inventors will generate a much wider and diverse set of explorations than when the development is under the control of one mind or organization.

This flags still another limitation of the "pool" or "mining" models. In these models the "fish" or the "minerals" are out there and known (with perhaps some uncertainty) to all parties. But with the technological "prospects," and perhaps even real life mineral prospects, no one knows for sure what possible inventions are in the technological pool. n144 It is not even generally feasible to assign probabilities to possible outcomes on which all knowledgeable people will agree. Indeed different parties are almost certain to see the prospect differently. Because of this uncertainty, development of technology is critically different from other common pool problems. The real problem is not controlling overfishing, but preventing underfishing after exclusive rights have been granted. The only way to find out what works and what does not is to let a variety of minds try. If a property right on a basic invention covers a host of potential improvements, the property right holder can be expected to develop the basic invention and some of the improvements. But we would expect a single rightholder to underdevelop -- or even ignore totally -- many of the potential [*874] improvements encompassed by their broad property right. n145

Of course, Kitch's notions about how a broad patent prospect can be worked out by the patent holder do not preclude involving many minds. However, we regard as fanciful the notion that wider talent can be brought in without real competition through selective licensing practices. A substantial literature documents the steep transaction costs of technology licensing, n146 and there is indirect evidence that these costs increase when major innovations are transferred. n147 Moreover, various studies have indicated that transaction costs tend to be very high if licenses are tailored to particular licensees. n148 It is much [*875] simpler to grant roughly identical licenses to all who will pay a standard rate. In our own research, we have not found a single case where the holder of a broad patent used it effectively through tailored licensing to coordinate the R&D of others.

Although the preceding analysis applies specifically to patents, it is interesting that other types of property rights are limited in scope, perhaps for similar reasons. Kitch himself notes, for instance, that in mining law "[t]he mineral claim system restricts the area that can be claimed through rules that specify maximum boundaries in relation to the location of the mineralization," n149 and that boundaries are required to be clearly marked. n150 While there are no statutory limits on the number of claims an individual can make, n151 the law requires a claimant who has identified a mineral deposit n152 to work a claim actively before property rights will vest. n153 This places practical limits on the number and dimensions of claims. And state law, which establishes limited exclusive rights during the prospecting period prior to the grant of federal rights, similarly requires persistent and diligent work toward discovery on each claim for which protection is sought. n154

The obvious goal of these requirements -- to prevent hoarding and speculation -- is analogous to the goal of patent law doctrines designed to limit the breadth of patents. Both sets of rules recognize that although property rights assignments can make development of an asset more efficient, the scope of rights is crucial. Property rights that are too narrow will not provide enough incentive to develop the asset, while overly broad rights will preempt too many competitive development efforts. Kitch's prospect theory must be supplemented to take account of this important limitation on the breadth of property rights. n155

[*876] An interesting general point about the economic literature on property rights emerges from this analysis. Economists who theorize about property rights do not appear to have analyzed extensively the issue of how broad property rights should be. For the most part this work emphasizes the importance of defining property rights in the first place. n156 The usual assumption is that, with low or nonexistent transaction costs, the parties will bargain to a Pareto superior solution given any initial assignment of entitlements; therefore the "size" of the rights is not important. n157 However, as elaboration of the Coase theorem has made clear, the initial distribution of property rights can make a difference in the equilibrium level of output of the bargaining parties. n158 If one were to look at the patent scope problem from this view, one would conclude that the present authors favor a regime of property rights that limits the scope of a patent in such a way that inventors of significant improvements are in a strong bargaining position with respect to holders of broad patents. n159 This is not a particularly useful way of conceptualizing [*877] the problem, however, since unlike rights that somehow touch tangible property -- the usual subject of this analysis -- the allocation of property rights between technological pioneers and improvers is not a zero-sum game. n160

Undoubtedly our position is open to criticism. Rivalry no doubt causes waste. Yet we have little faith in the imagination and willingness of a "prospect" holder to develop that prospect as energetically or creatively as she would when engaged in competition. We are also skeptical about her ability to orchestrate development. Given the way humans and organizations think and behave, we believe we are much better off with considerable rivalry in invention than with too little. n161

Can we prove it? We can present empirical evidence that the granting of broad patents in many cases has stifled technical advance and that where technical advance has been rapid there almost always has been considerable rivalry. However, we grant that it is possible to see our evidence as not completely persuasive in this regard, or to posit that we have looked at only a few cases and that these might not be representative.

And even if our case is accepted that, up to a point at least, rivalry facilitates technical advance and unified control damps it, one can respond [*878] by saying "Yes, but what about the costs and the wastes?" We can rejoin that, in our cases at least, it is not evident that the waste caused by the presence of a broad patent is very considerable.

2. Clarifying Assumptions. -- Our argument rests on a simple premise: when it comes to invention and innovation, faster is better. What proof do we have that this is true? The answer lies in the work of scholars who have examined intensively the interrelation among research and development expenditures, invention, and productivity growth. Although there are still a great many unanswered questions in this field, n162 the following general points seem to be widely accepted: First, increases in research and development expenditures yield more inventions. n163 Second, the larger numbers of inventions from increased research and development have a positive effect on future productivity growth. n164 And third, productivity growth is important for economic well-being. n165

These findings support our argument only if there is a link between the speed with which innovations are introduced and the overall number of innovations. The research just sketched is of no help if the timing of an innovation is unrelated to the number of subsequent innovations. Here we must rely on simple economic reasoning. For the same reasons people prefer to have money in hand now, as compared to the same amount (and more, depending on the interest rate) later, society prefers to have improvements now, rather than later. Again, keeping in mind that at some point increased incentives for improvement will reduce the incentive to create a pioneer invention in the first [*879] place, the sooner improvements can be introduced the sooner the cost-saving (and welfare-enhancing) effects of those improvements will be felt by consumers. And, of course, the early availability of improvements will accelerate the pace with which second-and third-generation improvements -- that is, improvements on the improvements -- will be introduced. n166

But it is perhaps not enough to demonstrate the consistency of our thesis with basic economic concepts. Another means of validating our assumptions is by looking for consistency with the goals and purposes of the patent law itself. In its grant of priority to the first to invent; n167 its preference for an early reduction to practice; n168 and its provisions designed to encourage early filing of patent applications, n169 patent law favors not just invention, but early invention. Thus our concern that improvements be introduced as quickly as possible simply carries out a basic policy evident throughout the patent system. While there are those who may challenge the propriety of these goals from the standpoint of economic policy, it is both realistic and necessary for courts and the patent office to pursue the goals implicit in both constitutional and statutory provisions. Our assumptions, therefore, while not completely unassailable, are consistent with both economics and policy considerations.

In the remainder of this section we will consider several historical examples of how technical change proceeds in an industry. In the following section we explore industries whose development followed the different models, testing the relative efficacy of a pluralistic rivalrous system versus one in which technical advance is under the control of one or a few organizations. Our goal is to determine whether our theoretical understandings regarding the effect of patent scope in various industry types are consistent with the historical record. [*880]

B. Differences in Industrial Patterns of Technical Advance



We have noted earlier that, while most analyses of the effects of the patent system on invention assume implicitly that technical advance proceeds similarly in all industries, this assumption is mistaken: the pattern of technical advance varies significantly from field to field. One of the authors, Nelson, has concluded that at least four different generic models are needed. n170 The first describes discrete invention. A second concerns "cumulative" technologies. Chemical technologies have special characteristics of their own. Finally, there are "science-based" technologies where technical advance is driven by developments in science outside the industry. In each of these models patent scope issues take on a special form. In any industry one or another of these models may be applicable at any given time, or appropriate characterization may require a mix. But the mix differs from industry to industry, and so too, therefore, the salient issues involving patent scope.

What we call the discrete invention model corresponds to much of the standard writing about invention. It assumes that an invention is discrete and well-defined, created through the inventor's insight and hard work. In the standard discussions it may be recognized that the original invention can be improved, or even that improvement or complementary advances may need to be made if the invention is to be of much use. The basic invention may be amenable to tailoring for different uses or customers. But it is implicit that the invention does not point the way to wide ranging subsequent technical advances. It does not define any broad prospect. There are many inventions that fit this model, and these may be of considerable economic and social value. Two examples are King Gillette's safety razor n171 and the ball point pen, n172 and many new pharmaceuticals may also fit this model. n173 And in other industries technical advance appears largely to proceed through inventions of this kind. The consumer goods packaging industry is likely of this sort, n174 as is the toy industry. n175 For inventions and industries like these, while tight and broad control of a particular invention [*881] may enable a firm to profit handsomely, possession by that firm of a proprietary lock on the invention is not a serious hindrance to inventive work by many other firms. This stems largely from two features of these industries, one having to do with inventive inputs and the other with inventive outputs. As to inputs, discrete inventions do not typically incorporate a large number of interrelated components; they stand more or less alone. n176 On the output side, the products of discrete technology industries tend not to comprise integral components of some larger product or system; they therefore do not enable the development of a wide array of ancillary products.

However, in a number of technologies, the above characterization is quite inappropriate. In industries like those producing automobiles, aircraft, electric light systems, semiconductors and computers, technical advance is cumulative, in the sense that today's advances build on and interact with many other features of existing technology. n177 This by no means implies that technical advance is slow or inconsequential. Over time dramatic advance occurs in these technologies from improvements to one aspect or another, adding this new feature or that. n178 In many cases the technology in question defines a complex system with many components, usbcomponents and parts, and technical advance may proceed on a number of different fronts at once. n179 In these industries inventions may enhance some feature of a prior "dominant [*882] design," n180 or they may be incorporated into subsequent inventions, n181 or both.

There is much more at stake regarding allowed patent scope in these cumulative technologies than in those where inventions are discrete and stand separately. Particularly when the technology is in its early stages, the grant of a broad-gauged pioneer patent to one party may preclude other inventors from making use of their inventions without infringing the original patent. Two such examples are the Selden patent, which was used to control the development of automobiles, and Edison's successful attack on a broad patent covering light bulb filaments. n182 Thus, a broader pioneer patent may give one party legal control over a large area. Alternatively, in multicomponent products, broad patents on different components held by several inventors may lead to a situation in which no one can or will advance the technology in the absence of a license from someone else. As we shall see, these are not just theoretical possibilities; they describe the development of several important technologies.

Despite the nature of technical advance in cumulative-technology industries, improvement patents (discussed earlier) are no more common in these industries than in others. n183 This is because an improvement patent is undesirable for the reasons discussed above, n184 and because patent lawyers prefer to claim a new or improved component or subcomponent as a distinct product. Accordingly, it is important not to confuse the patent-law concept of an improvement patent with the commercial reality that, in some industries, technical advance proceeds cumulatively, i.e., via a series of improvements.

Technical advance in the chemical industries has some attributes that fit the discrete invention model, some that fit the cumulative technologies model, and some particular characteristics of its own. A new chemical product is in most cases a discrete entity, or it may encompass a particular class of products, like penicillin. But particular chemical product innovations seldom are the keystones to the development of large numbers of other chemicals. Although there are recognizable families of chemical products, the invention of one chemical species seldom gives more than general guidance in the development of other species. This is primarily a function of the complex and unpredictable [*883] relationship between chemical structure and function, most clearly evident in the pharmaceutical industry. n185 Sometimes, however, a new chemical entity turns out to have a wide variety of applications. n186 Because of this, not every chemical product invention shares all the features of a true discrete invention. At the same time, chemical processes tend to be improved along the lines of the cumulative technology model, and licensing and cross licensing are well-established practices in these industries. This tradition of licensing mitigates the potential impact of broad patents. As a result of these special features, scope decisions affect the chemical industries differently from others, a point we return to in Part III.

An invention in any of the three regimes described above may be assisted by recent developments in science. But technologies whose advance is predominantly driven by such developments, while rare, warrant special recognition. In these science-based technologies, n187 of which modern biotechnology is a prominent example, research and development efforts attempt to exploit recent scientific developments. n188 These scientific developments tend to narrow and focus perceived technological opportunities in the industry and concentrate the attention of inventors on the same things.

Such science-based technologies warrant analytic distinction for [*884] several reasons. In the first place, this is a context that engenders inventive races of the sort described earlier, particularly if it is anticipated that the first to apply a scientific finding will get a patent of considerable scope. Many are rushing toward the same objective that all see as feasible and several will get there, but only the first receives a patent. Second, new scientific and technological developments "in the air" open the possibility of a major advance over prior practice, and the contribution made by the individual or firm who first makes these possibilities operational may be relatively small. n189 The invention may diverge from "prior art," in the sense of actual technological accomplishments, and sweep the market, yet still be only a successful application of knowledge that is apparent to the scientifically sophisticated. n190 When this is a possibility, the patent system should be particularly careful in awarding patents of broad scope. Third, and this is where our focus will be, there is a real danger that allowing patent scope to be overbroad may enable the individual or firm who first came up with a particular practical application to control a broad array of improvements and applications.

We now turn to a more detailed discussion of these models of technical advance, with an eye toward what they can teach us about the effects of patent scope.

III. EFFECTS OF PATENT SCOPE IN VARIOUS INDUSTRIES



Because we are concerned with the effects of patent scope decisions on the subsequent development of technology, we are not interested in the cases of discrete invention. We deal with what we have called cumulative technologies, chemical technologies and science-based technologies, in that order.

A. Cumulative Technologies



We have asked two questions about the effects of broad patents on cumulative technologies. One concerns the consequences of "pioneer" patents. We wish to test the validity of the hypothesis that the granting of broad patents is likely to make subsequent invention and development more orderly and productive. The second question is how the presence of broad patents on components of a cumulative technology affects subsequent development.

One must keep in mind, however, what we are not testing. We do not [*885] ask whether any patent should have been granted in the following cases. We take it as axiomatic that some degree of patent protection is necessary and desirable. And we do not ask whether the scope of the patents discussed should have been limited to the precise embodiments the inventor had developed when the patents were filed. We accept that patents claiming the general inventive principle were justified; and we focus on the impact of broad scope on the environment for subsequent development and improvement.

1. Electrical Lighting Industry. -- The chain of reasoning in our critique of the prospect theory, and our view of the patent system, is consistent with most of the historical evidence on cumulative technologies. The early electrical illumination industry illustrates this most clearly.

Patents played a very important part in this industry from the beginning. In the field of incandescent lighting, Edison's early patent gave his company, later General Electric, a dominant position. But in certain other sectors, most notably arc lighting and the production of dynamos, efforts to establish dominance via a single broad patent failed. The contrast between these sectors, where entry was easy and competition for improvements was intense, and the incandescent lighting field is noteworthy for our purposes. Most importantly, the history of the early electrical industry supports the notion that broad pioneering patents can play a pivotal role in the evolution of industry structure.

No single patent better illustrates this than Edison's U.S. Patent 223,898, issued in 1880. This was "the basic patent in the early American incandescent-lamp industry," covering the use of a carbon filament as the source of light; n191 it proved to have a profound effect on the industry until it expired.

Although the Edison General Electric Company had some difficulty establishing the validity of its basic patent, once it did the industry changed drastically. In 1891, U.S. Patent No. 223,898 was held valid and infringed by a competing design. n192 General Electric officials then quickly obtained a series of injunctions that shut down a number of competitors. n193 As the aptly-named industry historian Arthur Bright stated, "For twelve years [after the issuance of the 223,898 patent] competition had been possible; it suddenly became impossible." n194 The company's market share grew from 40 to 75 percent; entry into the industry slowed from 26 new firms in 1892 to 8 in 1894, the last year of [*886] the patent's life; n195 and the steady downward trend of lamp prices slowed until the patent expired. n196

More importantly for our purposes, the validation of Edison's broad patent slowed the pace of improvements considerably.

Even as the courts were passing on the Edison lamp patent in 1891, the Edison General Electric Company . . . . [recognized that it] gradually had been slipping backward in its commercial position, particularly since 1886 . . . . Its technological contributions were becoming relatively smaller than they had been during the early [eighteen] eighties. n197

This was especially true in Great Britain, where the Edison Company's patent position was even more commanding, due to its control of a basic patent on a process for producing carbon filaments. A series of court victories over its largest competitors gave the British "Ediswan" company "a practical monopoly of incandescent-lamp production." n198

Given the lack of competition, it is perhaps not surprising that the pace of technical advance slowed. According to the historian Bright:

After the introduction of the incandescent lamp and its first rapid changes . . . . the Edison Electric Light Company did not introduce many important new developments. Edison himself turned to other problems, and the company's technical leadership in incandescent lighting was not revived until after the merger [that formed General Electric in 1896]. n199

Prior to the enforcement of the patent, Edison's competitors were quickening the pace of technical advance:

Despite the improvements in the Edison lamp, a number of its competitors had improved their lamps even more rapidly . . . . Efficiency advantages permitted many of the other American concerns to compete very successfully with the Edison lamp after 1885 . . . until the corporate reorganizations and the establishment of patent supremacy regained for the Edison lamp commercial supremacy as well. n200

The same was true overseas: "In England, filament improvement was almost entirely halted during the period of Edison patent monopoly [*887] from 1886 to 1893." n201 Bright concludes:

The lengthy and expensive patent struggle in the lamp industry from 1885 to 1894 was a serious damper on progress in lamp design, although process improvement continued. The Edison interests concentrated on eliminating competition rather than outstripping it. . . . After 1894, when it was no longer protected by a basic lamp patent, General Electric devoted more attention to lamp improvement to maintain its market superiority. n202

Thus the broad Edison patent slowed down progress in the incandescent lighting field. The lesson, however, is not that this patent should not have been granted. It is rather a cautionary lesson: broad patents do have a significant impact on the development of a technology and hence on industry structure, and this should be reflected in those doctrines that collectively determine patent scope.

Two other sectors of the electrical industry -- ones where broad patents were invalidated -- demonstrate what can happen in the absence of dominant patents. The first was in the production of power generation dynamos, where the Brush Company attempted to establish patent dominance. Brush, together with several other companies, acquired a patent they thought "would give absolute control of all dynamo manufacture in the United States." n203 But the courts thought otherwise; the patent was found to have lapsed when a foreign counterpart patent reached the end of its term. n204 As an historian of the industry describes it:

The effect of the decision was to free the dynamo from patent control. Anybody could manufacture it. It was only minor details in dynamo design and construction -- such as particular coil windings or commutators -- which were patentable. n205

Because there were no broad patents to discourage entry, entry was easy and competition for improvements was intense. n206

[*888] The second failed attempt to establish dominance by way of a broad patent also involved the Brush Company. In 1884 the company brought a test infringement case involving its basic patent on a double-carbon arc light. n207 Unfortunately for the Brush Company, the court found that the defendant's design did not incorporate a key feature of the Brush patent, and thus held that there was no infringement. n208 This ruling had an important effect: "[p]atents were consequently not a handicap to entry into the industry. Firm after firm was organized to manufacture its own arc-lighting system. At one time, nearly fifty different firms were making arc-lighting equipment." n209

2. Automobiles and Airplanes. -- We move now to two infamous cases regarding pioneer patents: the Selden patent in the development of automobile technology, n210 and the Wright patent's influence on the growth of aircraft technology. As we have seen, the Selden patent claimed a basic automobile configuration, one using a light-weight internal combustion engine as the power source. The Wright patent was on a broadly defined airplane stabilization and steering system. In both of these cases, the holders of the pioneer patent engaged in extensive litigation against companies that did not recognize the patent, n211 and [*889] the Wrights refused to license theirs. n212 Our question is how the presence of these patents affected the evolution of the technologies.

The Selden patent had as its key claim the use of a light gasoline-powered internal combustion engine. This claim was extremely broad and covered a myriad of possible embodiments. n213 Contrary to the prospect theory, however, neither Selden nor his assignee used the patent to orchestrate the efficient improvement of automobile technology; there was no policy of "developing the prospect." n214 They were willing to license anyone who would acknowledge the validity of the patent and pay royalties; to this end they formed the Association of Licensed Automobile Manufacturers. n215 But the Association's purpose was to collect royalties, and perhaps control competition in the industry, n216 rather than to facilitate orderly technological development.

[*890] But did the presence of the Selden patent actually hinder technological progress in the industry? That is perhaps a bit more speculative. Law suits based on it surely did absorb considerable time and attention of people like Henry Ford, whose production methods revolutionized the industry. n217 Perhaps more importantly smaller firms may have been put off by the threat of suit. At this early stage in the history of the technology, those that left the industry or chose not to enter may well have taken valuable improvements with them.

An interesting result of this experience with patent litigation was that, even before the Selden patent was pruned back in 1911, n218 the automobile industry, through the Association, developed a procedure for automatic cross licensing of patents. While formal agreements to cross license all new patents no longer exist, the practice of relatively automatic cross licensing has endured to the present.

The Wright brothers patent is different in a number of regards. First of all, the achievement described in the patent -- an efficient stabilizing and steering -- system was in fact a major one, and it did enable a multiplicity of future flying machines. n219 Second, the Wright brothers were very interested in producing aircraft and in improving their design, and they did so actively. However, there were other important people and companies who wanted to enter the aircraft design and manufacture business. They had their own ideas about how to advance the design of aircraft, and they strongly resisted being blocked by the Wright patent. In this case, and others, it turned out to be extremely difficult to work out a license agreement that satisfied both the holder of a broad patent and an aggressive potential competitor who believed that there was a lot of his own work in his design. The early attempts by the Wright Brothers and Glenn Curtiss, who was the most prominent such potential competitor, came to naught. Litigation followed. n220

There is good reason to believe that the Wright patent significantly [*891] held back the pace of aircraft development in the United States by absorbing the energies and diverting the efforts of people like Curtiss. The aircraft case is similar to that of automobiles in that the problems caused by the initial pioneer patent were compounded as improvements and complementary patents, owned by different companies, came into existence. The situation was so serious that at the insistence of the Secretary of the Navy, during World War I, an arrangement was worked out to enable automatic cross licensing. n221 This arrangement, like the licensing of automobile patents, turned out to be a durable institution. By the end of World War I there were so many patents on different aircraft features that a company had to negotiate a large number of licenses to produce a state-of-the-art plane. n222

3. Radio. -- The case of radio in the United States warrants at least a brief recounting, for it is an excellent example of what happens when several companies each hold patents of broad scope. The earliest radio patent was a broad patent granted to the British inventor Marconi in the field of radio transmission. n223 Marconi also invented and acquired rights to the basic technology for tuning, n224 which he controlled until 1914, and the basic Fleming patent on the two element vacuum tube, or diode. n225 These patents helped the Marconi Wireless and Telegraph Company establish an imposing presence in the early radio industry, which was dedicated primarily to large-scale commercial uses such as ship-to-shore communications.

AT&T, as part of its radio operations, n226 acquired rights to two very fundamental patents on the triode vacuum tube, an early radio wave amplification device patented by Lee De Forest. n227 While technically [*892] only an improvement on Marconi's diode, the triode was in fact a very significant advance; it was called "the heart and soul of radio." n228

Several other firms had important patent positions. General Electric entered radio as a natural extension of its expertise in electricity generating systems. It controlled the important Alexanderson patents on the electric alternator, the signal generation invention that made long-range transmission possible. n229 Westinghouse also joined the industry, mostly on the strength of patents on receiving technology, which served as the basis of the firm's successful entrance into the inexpensive home receiver market. n230 Other companies also held American rights of varying breadth over other important radio technologies. n231

The situation soon became similar to that in the aircraft industry, where different companies could block each other from using key components. A good example is the deadlock between the Marconi Company and the De Forest interests, a classic instance of blocking patents. Marconi's diode patent was held to dominate De Forest's patented triode, n232 yet neither party would license the other. n233 As a consequence, no one used the admittedly revolutionary triode for a time. This is a good example of a case where the reverse doctrine of equivalents might have been invoked to permit De Forest to practice his improvement. n234

In at least one other area as well -- long-range transmission -- licensing proved difficult. n235 The upshot was that no one could produce state-of-the-art radio technology without being threatened by litigation. n236 Radio is thus a canonical instance where the presence of a [*893] number of broad patents, which were held by different parties and were difficult to invent around, interfered with the development of the technology. n237 The various pioneers formed RCA to break the deadlock; the new company promptly acquired the American rights to the Marconi patents. n238 The companies that owned most major radio patents became RCA shareholders. n239 With all the constituent radio technologies under one roof, RCA established itself as the technical leader in radio and dominated its advance for many years. n240

As shown by the cases of autos, airplanes, and radios, the many early inventors in cumulative technologies often perform overlapping research. This may lead to blockages unless basic patents are not present, or routine licensing and cross licensing is instituted. We next consider the former possibility by describing important post-World War II technologies that have advanced rapidly because no one held a pioneer patent that was used to restrict access. At the end of this section, we discuss the licensing solution and its impact on our analysis of patent breadth.

4. Semiconductors and Computers. -- Semiconductors are a good example of a technology that developed without patent blockages. There are two instances in the history of this technology where a broad-gauged patent was issued which could have given its holder control over a large "prospect," but in fact did not. One involved the initial transistor patents held by AT&T. Because of an antitrust consent decree, [*894] AT&T was foreclosed from the commercial transistor business. n241 Some have argued that it is not clear whether AT&T would have gone into the merchant transistor business even in the absence of a consent decree. n242 In any case, given that it was not going to do so, AT&T had every incentive to encourage other companies to advance transistor technology because of the value of better transistors to the phone system. AT&T entered into a large number of license agreements at low royalty rates. n243 Many companies ultimately contributed to the advance of transistor technology because the pioneer patents were freely licensed instead of being used to block access.

The second instance involved the parallel inventions of the integrated circuit (by Texas Instruments) and the Planar process for producing them cheaply (by Fairchild Instruments). Both of these companies obtained patents on their own inventions, which meant that each had to license the other to produce integrated circuits effectively. n244 Cross licensing was favored by the government; the Department of Defense, which for some time had provided the lion's share of the market for semiconductors, had a strong interest in seeing these important technologies become broadly available throughout the industry. n245 Again, the absence of a single, broad patent assisted the rapid development of an industry.

The second recent cumulative technology developed without strong, broad patents is electronic computers. Although original computer inventors Eckert and Mauchley did file for and receive a patent on their basic ENIAC design, the patent was ruled invalid because of a judgment that the prior art included much of what they claimed. n246 Since this ruling, patents have played only a very minor role in the computer industry, and where patents are concerned, cross licensing is common. n247 As a result, the pace of technical change has been rapid. n248

5. Licensing and Cumulative Technologies. -- In many of the cases we have examined, licensing and industry consolidation emerged as solutions to patent blockages caused by patents. This would appear to have a bearing on our study. Does the consolidation of the radio industry in RCA, for example, support the position that development would have [*895] been more efficient had control been in the hands of one party from the beginning, in the form of one super-patent? Or does it imply that patent breadth was irrelevant -- consolidation would have happened even with narrow patents?

The first possibility seems remote, and there is indirect evidence that the second is wrong as well. The fact that many inventors and firms made important advances in various components of radio technology indicates that no one firm had the inventive firepower to develop radio on its own. And there is no reason to believe that one firm could have orchestrated the development of the technology, since there was no way to know in advance which inventors would cultivate expertise in each component, or which inventor's approach would work. There were no "proven" experts in transmission or reception that a firm could have granted licenses to, for example; experts emerged only when their inventions turned out to work. n249 And it would have been impossible to identify all the potential experts, since everyone was working on the various components simultaneously. n250 In any event, the inventive scramble that in fact resulted, while by no means optimal, did result in the fairly rapid commercialization of a complex, multicomponent technology. It also resulted in a patent tangle, one that might have been lessened if some of the key patents had been narrower. But it is difficult to see how a single broad patent would have led to more rapid commercialization. The ex post consolidation, in other words, simply does not imply that a broad ex ante "prospect" would have been effective in this case. n251

As to the second objection to our analysis -- that the radio industry would have consolidated regardless of patent breadth -- two points [*896] seem relevant. First, narrower patents might have made consolidation unnecessary. If one or more firms could put together a complete radio system without infringing any patents, consolidation would not have been essential, at least for patent-related reasons. One candidate is General Electric: the only essential component for which patent blockage was a problem was the triode; n252 if De Forest's patent had been narrower, n253 or if inventor Edwin H. Armstrong had won his interference with De Forest, n254 General Electric might have put together a noninfringing system.

Second, even if narrower patents would not have prevented the deadlock, they might have helped break it sooner. Perhaps without the value of a "holdup right" on an essential component of radio technology, the firms would have been content to contribute their patents to a pool and compete on the basis of improvements and price competition. n255 Finally, even if this industry eventually consolidated into one firm, there is no promise that all industries will do so. n256

There is also no reason to assume that when blockages arise industries will always turn to the deadlock-breaking solutions we have seen, patent pooling and cross licensing. Though we saw the emergence of cross licensing among aircraft manufacturers, the impetus was war-time government pressure. n257 In the case of the light bulb industry, the government stayed out; when the firms finally pooled technology, it was only to effectuate the operation of a cartel. n258

There is therefore no guarantee that pooling, cross licensing, or consolidation will always emerge to break an industry impasse. And without these solutions there is nothing to mitigate the effect of broad [*897] basic patents in cumulative technology industries. Earlier we saw that theory offered a number of reasons to be concerned about these patents. The historical evidence available is consistent with this theory. In most instances this evidence can be read as supportive of our concerns about the effects of broad patents on cumulative technology industries. Chemical industries, which we turn to next, tell a different story.

B. Chemical Industries



Chemical industries produce an incredibly diverse range of products, from bulk chemicals like sulfuric acid, to synthetic materials like plastics, to pharmaceuticals. n259 Despite the diversity of products, however, invention in the chemical industries shares several key attributes. To a large extent chemical product invention tends to fit the "discrete invention" model described earlier. n260 Thus product patents tend to define a well delineated class of substances. n261 Valium is valium and, although subject to some variation, sulfuric acid is sulfuric acid. However, research and development on new chemical products is subject to an unusual degree of uncertainty and costly experimentation, both because it is difficult to predict the precise chemical structure needed to achieve a given end and because the effects of using a new chemical substance in a particular way can be startling. n262 Further, once a new product or use is discovered, it is easy for a competitor to replicate. [*898] Thus patent protection on products or novel ways of applying them is vital if the inventor is to reap returns. n263

 

In contrast with product technology, most chemical production processes evolve cumulatively in the sense discussed earlier. The first versions of new chemical processes tend to be amenable to a wide range of improvements. Thus one might expect to see the same kinds of problems regarding chemical process patents as we have seen in our examination of other cumulative technologies in the section above.

To analyze the importance of process and product inventions in the chemical industries, it is helpful to disaggregate those industries into three groups: bulk chemicals, synthetics, and pharmaceuticals.

1. Bulk Chemicals. -- Bulk chemicals consist of products like sulfuric acid, ammonia, ethylene, and other substances that have been known and widely used for some time. Many are natural substances. In any case there are no effective product patents on bulk chemicals. n264

As a consequence, most research and development is concerned with creating new or improved processes. The development of chemical process technology tends, as noted, to be cumulative; at any time there tends to be one process that is the dominant mode of production. From time to time a dominant process is superseded by a new one. And the early patent or patents on that new process have the characteristics of "pioneer" patents. However, these patents have not generally been used to control subsequent development, which by and large has proceeded with multiple sources of initiative. n265 This is due primarily to the inherently limited power of control conferred by patents in the bulk chemical field. n266 Pervasive cross licensing in chemical industries confirms this. n267

[*899] Thus, until 1861 the Leblanc process dominated the production of alkalis. n268 This process was widely licensed and a number of different companies contributed to its improvement. n269 When, in 1861, the Solvay process was developed and patented, the original patent holder also had a chance to control future development of the process. n270 However, here too the policy of the original patent holder was one of reasonably wide licensing of the basic patent. A number of different companies made improvements; these were also cross-licensed. n271

Of course there are patent suits and short-term hold ups in the field of bulk chemical process technology, but these problems are usually settled and licensing is a general practice. n272 The recent development of new processes for making acrylamide is a good example. Acrylamide is an organic chemical commonly used to make polymers for "water treatment, pulp and paper processing, textile treatment, food processing and other applications." n273 Until the 1960s it was made in a two-step process using sulfuric acid and ammonia. In the mid 1960s, researchers at several different companies all began investigating ways to improve the traditional process. n274 Both Standard Oil and American Cyanamid came up with processes using copper as the catalytic agent. Dow Chemical also made several patentable inventions in this field. n275

Lawsuits were filed. Standard Oil sued American Cyanamid arguing that American Cyanamid's process infringed Standard Oil's patent. The court ruled against Standard Oil in this case. n276 On the other [*900] hand, Dow successfully sued American Cyanamid for infringing its patents. n277 However, after this round of legal scuffling, the companies cross licensed each other. No single company tried to hold to itself the right to use the new technology or control its future development. n278

In short, the pattern of development in bulk chemical process technology is similar to several of the cases of cumulative technologies considered earlier. It is sometimes possible to obtain a fairly broad patent when a new technology is invented. n279 This has the potential to give its holder a measure of control over subsequent development. However, by and large the chemical companies have not used their patents that way, partly under the pressure of competing inventions. These firms choose instead to license or cross license. Thus several companies tend to be involved in the subsequent development of the technology.

2. Synthetics. -- Product patents are slightly more important in the field of synthetic materials, where they are sometimes connected closely with process inventions; research on a new process for making an established product may yield a distinct and patentable version of the product. n280 But just as in bulk chemicals, reasonably liberal licensing is common in the synthetic chemical industry. n281

When Du Pont wanted to enter the business of producing Rayon it took out licenses on the product and the key processes from the French firm that held them. n282 Du Pont similarly took out a license on Cellophane technology. n283 Subsequent research and development at Du Pont on both of these products significantly improved them. n284 In turn, Du Pont licensed Nylon to both Imperial Chemical Industries of Great Britain and IG Farben of Germany. n285 Both of these companies [*901] later came up with variants on the original Nylon.

The fact that product patent claims are narrowly bounded keeps the advance of synthetic material technology competitive. Thus Du Pont's Nylon provided a superior alternative in many uses to the earlier Rayon. n286 And newer fibers like Dacron and Orlon subsequently replaced some of Nylon's market. n287

Another good example of the interdependence of product and process technology in synthetic materials is the effort to develop an improved process for the manufacture of polyethylene. Research teams at several firms worked on this project simultaneously. In the 1950s researchers at the Max Planck Institute, led by a chemist named Karl Ziegler, invented a superior process, based on a new understanding of catalytic compounds. n288 Not only was the new process patentable, but due to the relatively restrictive claims on the older polyethylene patent, the product it produced was outside the scope of Imperial Chemical's basic patents. n289

In turn, work by an Italian chemist, Giulio Natta, led to significant improvements in the Ziegler process. Natta's group also discovered a way to produce polypropylene, another important polymer. n290 Groups at other companies and research institutes were following the same trail. At least five different companies filed product patents on a version of polypropylene between 1953 and 1955. n291

Needless to say, the customary round of law suits resulted, and [*902] dragged on for some time. n292 However, the result was not that a single company controlled the basic technology and improvements, but rather a series of cross-licensing agreements which kept the technology open to a number of firms. n293

3. Pharmaceuticals. -- We turn now to the two matters regarding the scope of chemical patents which are especially important in the pharmaceutical industry: what to do when someone discovers a new use for an established product, and how to treat a process invention that yields a much purer form of a natural substance than was available earlier.

Earlier we observed that chemical products have a surprising range of uses. Often some of these cannot be foreseen when a product is invented and patented. In a number of cases researchers looking for a [*903] way to meet a new need will discover that an old product can do the job. In other cases, the discovery of a new use may be accidental -- a byproduct of looking for something else. In either case, this is important inventive work that ought to be encouraged and rewarded. How to do this? The Patent Office and the courts have been struggling with this issue for some time.

The general solution has been to award a process patent to the discoverer of a new use. We cited a nonpharmaceutical example earlier, the case of Rohm & Haas v. Roberts Chemical Co.. n294 In this case the defendant's patent on use of a well-known product as a fungicide was upheld because this use was not anticipated or claimed in the original patent. n295 This process patent would not enable the patent holder to produce the product in question, but rather only to control its new use. If the use is an important one, such a process patent can provide a substantial reward to the patent holder. This is an important doctrine in the pharmaceutical industry, where new uses are often discovered. n296

Another special problem that crops up in the chemical patent field involves inventing a synthetic version of a substance found in humans or animals. Typically the discovery involves enhancing purity or lowering cost. Today this issue arises mainly in the field of biotechnology, but the problem has existed for some time. Thus in 1911 Learned Hand upheld a product patent on purified human adrenalin made via a new process. n297 The patent was not simply on the process, but also on the purified natural substance.

The problem with this practice is that it grants patents of unnecessarily wide scope. The adrenalin patent would be infringed by the use of a radically different, and better process for making the same natural product unless the characteristics of the product were judged substantially different. Yet the argument is not convincing that what the original inventor invented was the product, in addition to her particular process for making it.

The recent case involving Genentech, which we mentioned earlier, illustrates the issue. Genentech had invented a recombinant DNA method for producing the human blood clotting protein factor [*904] VIII:C. n298 That process had major advantages over an earlier, patented technique of purifying the substance drawn from natural blood. Genentech's process was not only better; it was completely different. Yet in the first part of the case, the court upheld the earlier patent, held by the Scripps Institute, on the ground that it was a legitimate product patent and thus Genentech's new method of producing it was an infringement. n299

In a later ruling, the court invalidated the Scripps patent, saying that it did not adequately disclose the purification method that Scripps itself judged best. n300 But the court did not retract its earlier judgement that a product patent was quite legitimate in this case. We think this is unfortunate social policy. It might well inhibit technical advance in biotechnology, where much invention involves improving ways to produce purified natural products. If the initial patent is granted on the product, rather than the process for making it, subsequent process research by others will be discouraged. This is a good example of a prospect that will likely reduce competition for improvements. While licensing by firms can mitigate this problem, there is no guarantee that this will take place at such an early stage in the industry. n301

The doctrine of reverse equivalents might be employed to limit the blocking power of product patents in appropriate cases. Under this doctrine a court could rule that an important process invention yielding a more purified form of the product escapes infringement. Although compulsory licensing might be another option, our law does not for the most part permit judicially mandated licensing. n302

C. Science-Based Industries

Earlier, we discussed what makes an industry science-based. n303 Perhaps the most dramatic contemporary example is the biotechnology industry. Scientific advances, especially in molecular biology and biochemistry, created this industry, and continue to feed it ideas, theories, discoveries, and techniques. n304 Other examples include the chemistry [*905] of catalysis and semiconductors during the 1950s, n305 and the burgeoning new field of superconductivity. n306 Because science-based industries rely so heavily on scientific discoveries, one relevant patent issue is the appropriate scope of patents in the face of the (usually published) science that makes invention in these industries possible.

The modern biotechnology industry is built around two different sets of technologies: recombinant DNA and monoclonal antibodies. Both of these are based on prior, more general advances in molecular biology and both were initially discovered and employed by scientists concerned with pure research. One of these technologies was originally developed in 1975 by Kohler and Milstein, who discovered that individual immune system cells, which generate antibodies to a specific antigen, could be fused with immortal cancer cells, to create a small "factory" for producing antibodies. n307 They did not take out a patent on their discovery. They were awarded a Nobel prize. n308

The pathbreaking Kohler-Milstein research almost immediately was recognized as opening up a myriad of commercial possibilities. n309 Hybritech was an early entry into the race to develop applications. It was the first to use monoclonal antibodies in diagnostic kits sold to doctors and hospitals to identify the presence of diseases (e.g., AIDS) or heightened hormone levels (e.g. pregnancy tests). It received a patent covering this whole family of diagnostic kits.

Other companies saw exactly the same opportunity, if not so quickly. Monoclonal Antibodies, Inc. was one of these, and it created a similar technique after Hybritech. Monoclonal Antibodies, Inc. made and sold these kits, and Hybritech sued. n310 Monoclonal defended by claiming the Hybritech patent invalid, at least in its broad scope, because given the work of Kohler and Milstein the generic technique was obvious. The trial court recognized the argument, and acknowledged:

[T]he major advance was the invention of Kohler and Milstein [*906] in the making of monoclonal antibodies . . . . Onece the scientific community had the monoclonal antibody it was obvious and logical to those expert in the field to use them in known assays as substitutes for . . . polyclonal antibodies . . . of inferior qualities. n311

However, on appeal, the patent was held valid. Granted, the call was not an easy one: Hybritech clearly invented something. The question was, given that it was building on public science, what was the limit of its contribution? The Patent Office allowed Hybritech a broad prospect and the court concurred.

While a case has not come to court yet, the Patent Office also allowed Genentech a very broad prospect on the second major technology of the new biotechnology industry, expression of recombinant proteins. The basic genetic technique was developed earlier by two scientists, Cohen and Boyer. n312 The two scientists involved saw their basic technique -- the insertion of a specific gene into a host cell and subsequent expression of the protein product for which the gene codes -- primarily as a contribution to ongoing public science. Their universities urged them to take out a patent, which they did, but the patent is licensed to all comers. n313

Genentech's patent is an extension of the Cohen-Boyer work. n314 It covers the basic technology of gene expression, where the firm clearly made a major early contribution. n315 Their contribution was to refine existing gene expression techniques to achieve the first successful expression of a human protein in a bacterium. n316

In their specification, the inventors describe one particular technique for expressing and recovering proteins and apply this technique to the production of two polypeptides. n317 The technique disclosed in the patent no doubt legitimately covers many more specific embodiments than those expressly disclosed. But it can be argued that they simply were the first to bring to practice techniques that persons "skilled in the art" knew could be made to work. It is difficult to tell yet whether the breadth implicit in this patent will hold up, but it has created a good deal of trepidation in the industry. n318 According to the [*907] head of a rival biotechnology firm, "If interpreted most narrowly, there are certain bacterial [production] systems that wouldn't even be covered. If interpreted most broadly, it could cover all production systems in bacteria, yeast and cells." n319

Fortunately for the industry, an even broader patent on gene expression was rejected on obviousness grounds because several of the inventors published results prior to the invention. n320 The investigators had discovered that a gene for a non-operational protein taken from a frog could be inserted into a bacterium and expressed there. n321 On the basis of that research they filed a patent claiming a process for producing proteins comprising "linking a natural or synthetic heterologous gene [i.e., one from a foreign source] . . . to [an] indigenous [bacterium] gene portion." n322 It is worth noting that there is no indication that these claims would have been rejected because of their breadth. Thus if the prior publication had not been judged to render the claimed invention obvious, it might have received a patent. Judging from the quoted claim language, this would have been very broad indeed.

Biotechnology is not the only industry where scientific breakthroughs [*908] sparked a scramble to obtain broad patents. The current rush to obtain patents over superconductors demonstrates that patent positioning often is important at the birth of science-based industries. n323

As a new science-based technology matures, the issues relating to patent scope change largely because particular technologies become established. Thus the early work on catalysis was science based. But as catalysts were developed, further innovation became more cumulative than science-based. Step-by-step process improvements now dominate the field, succeeding the early advances that came quickly on the heels of the Ziegler and Natta research. As a result, the issues involved in setting appropriate patent scope change as an industry advances.

* * * * *


NOTES
* Associate Professor, Boston University School of Law.

** Henry Luce Professor of International Political Economy, ColumbiaUniversity.

We would like to acknowledge the helpful comments and suggestions receivedfrom the following people: Harold Edgar, Donald Chisum, Rebecca Eisenberg,Joe Brodley,Steve Marks, and participants in Faculty Workshops at Boston University and Columbia University law schools. They contributed helpful advice, but none of the shortcomings that may remain. We are grateful for support from the Julius Silver Programin Law,Science and Technology at the Columbia Law School, and from the SloanFoundation through its funding of the Consortium on Competition andCooperation.

n122 W. Nordhaus, supra note 3.

n123 See Kaplow, The Patent-Antitrust Intersection: A Reappraisal, 97 Harv. L. Rev. 1813, 1855-67 (1984). Compared with other economic analyses of restrictive licensing practices, Kaplow's approach differs in that he is careful to emphasize the net social benefits of granting a particular patent. Kaplow criticizes Bowman and Baxter for relying on the notion that the individual inventor should be given a patent and allowed to license it using restrictive practices if that inventor's reward is less than or equal to the value of her invention to society. Id. at 1849-54. "Such a view," according to Kaplow, "incorrectly focuses on total social benefits, rather than net social benefits (the excess of total benefits over total costs)." Id. at 1828. Kaplow thus structures his analysis of an optimal system so as to take account of the social cost of granting a patent or permitting a restrictive practice.

n124 See R. Gilbert & C. Shapiro, supra note 2, at 2.

Increasing the breadth of the patent typically is increasingly costly, in terms of deadweight loss, as the patentee's market power grows. When increasing the length of the patent, by contrast, there is a constant tradeoff between the additional reward to the patentee and the increment to deadweight loss . . . . So, the socially cost-effective way to achieve a given reward to innovators is to have infinitely-lived patents with enough breadth to attain the required reward level.

Id.; P. Klemperer, supra note 2, at 2 ("Since any single prize . . . will induce the same r&d activities, we can equivalently think of choosing [patent length and breadth] to minimize the social cost stemming from the resulting monopoly provision rather than the perfectly competitive provision of a new product . . . .").

n125 For an overview of work in this area, see M. Kamien & N. Schwartz, Market Structure and Innovation 105-12 (1982).

n126 See, e.g., Lippman & McCardle, Dropout Behavior in R&D Races with Learning, 18 Rand J. Econ. 287 (1987). See supra notes 12-14 and accompanying text. Note that in his article on restrictive licensing practices Kaplow leaves room for a consideration of some long-term effects:

The possibility of adverse effects from long-run changes in market structure occurring over the patent life adds another element to aggregate social cost and reinforces [my] conclusion about the relation of private to social benefits [i.e., that private benefits will exceed social benefits due to the presence of social costs not borne by the patentee].

Kaplow, supra note 123, at 1828 n.35.

n127 See supra note 124.

n128 At least insofar as both length and scope enter into the "tradeoff" analysis. Note, however, that broad claims influence who will be involved in further work in the technology and on what terms. This is different from giving a patent holder a long time to control a particular invention, as Gilbert and Shapiro note. See R. Gilbert & C. Shapiro, supra note 2, at 2 (explaining that their model focusses on patent scope because increases in scope have greater preclusive effect than increases in length).

n129 See R. Gilbert & C. Shapiro, supra note 2, at 4-5 (effect of substitutes on price patentee can charge); P. Klemperer, supra note 2, at 3 (modelling cost of precluded substitutes by picturing consumers travelling along a product distribution line (Hotelling model)). The article by McFetridge & Rafiquzzaman, supra note 2, raises the same general problem. These authors argue that the greater the degree of postpatent competition, or potential competition, the greater the price discipline on the innovator. The degree of competition is dependent on the scope of protection given to the innovator. In this model competition eats into the percentage of cost savings brought about by the innovator's invention. See id. at 104. This model points generally to the same conclusions reached in the Gilbert and Shapiro paper. But note that it considers only the effect of patents on the development of substitutes for that patented technology and not the effect of the patent on improvements and extensions of the patented technology. It is in this sense still more static than dynamic in its approach and, hence, different from the view taken here.

n130 But cf. R. Gilbert & C. Shapiro, supra note 2, at 7-8 (cautioning in conclusion that infinitely-lived patents, with reward adjusted solely by variations in scope, could "retard subsequent innovation by establishing monopoly rights to an entire line of research").

n131 See, e.g., Barzel, Optimal Timing of Innovations, 50 Rev. Econ. & Statistics 348 (1968); Dasgupta & Stiglitz, Uncertainty, Industrial Structure and the Speed of R & D, 11 Bell J. Econ. 1 (1980); Wright, The Resource Allocation Problem in R & D, in The Economics of R & D Policy 41 (G. Tolley ed. 1985).

n132 See, e.g., Tandon, Rivalry and the Excessive Allocation of Resources to Research, 14 Bell J. Econ. 152 (1983); Wright, supra note 131.

n133 See, e.g., Dasgupta and Stiglitz, supra note 131; Lee & Wilde, Market Structure and Innovation: A Reformulation, 94 Q.J. Econ. 427 (1980); Scherer, Research and Development Resource Allocation Under Rivalry, 81 Q.J. Econ. 359 (1967). For recent treatments of the topic, see Lippman & McCardle, supra note 126; see also Wright, supra note 131, at 41, 49-56 (describing the relationship between the general common pool model and what we call "race" models: "The dissipation of the benefits of research before the socially optimal time . . . is a dynamic intertemporal version of the same type of market failure [described in the common pool models].").

n134 See, e.g., Dasgupta, Patents, Priority and Imitation or, The Economics of Races and Waiting Games, 98 Econ. J. 66 (1988) (exploring conditions that make waiting more profitable than entry in races to invent); Katz & Shapiro, R & D Rivalry with Licensing or Imitation, 77 Am. Econ. Rev. 402 (1987) (exploring effects of post-invention dissemination, i.e., licensing or imitation, on two-firm strategic race to invent).

n135 Kitch, supra note 12, at 276-77. In some respects, William Kingston's idea of an "innovation warrant" is similar to the "breathing room" aspect of the prospect theory. Kingston, The Unexploited Potential of Patents, in Direct Protection of Innovation 1, 1-34 (W. Kingston ed. 1987). What Kingston has in common with Kitch is a focus on incentives to develop markets. But Kingston's proposal is to give patent-like "innovation warrants" to the first firm to commercialize even a minor innovation. This, of course, differs from Kitch, who implicitly assumes the desirability of maintaining the patent system's current focus on technological advance, rather than on mere market innovation.

n136 Kitch, supra note 12, at 279.

n137 Kitch notes that U.S. mining law performs these two functions as well. Id. at 271-75.

n138 Id. at 286.

n139 Id.

n140 The concept originated with the economist Herb Simon. See Simon, Theories of Decision-Making in Economics and Behavioral Science, 49 Am. Econ. Rev. 253, 262-65 (1959); see also J. March & H. Simon, Organizations 140-41 (1958) (most decision making concerned with discovery and selection of satisfactory, rather than optimal, alternatives). This view is reflected in the work of some analysts of innovation:

The sluggishness of large firms in certain innovations has been explained by the desire to protect an investment in the then-current technology, satisfaction with the status-quo, underestimation of the potential demand for a new item, neglect of the inventor, and misdirection of research, as well as by incompatibility of bureaucracy and creativity.

M. Kamien & N. Schwartz, supra note 125, at 68. See generally R. Brenner, Rivalry in Business, Science, Among Nations 1-28 (1987). Brenner describes a broad and somewhat iconoclastic view of entrepreneurship as an activity brought on by frustration and adversity -- the need to take a gamble. He points out that an increase in rivalry can bring about these conditions, and thus ties increased rivalry and competition to increased innovation.

n141 The transition from entrepreneur to established, cautious firm can be breathtakingly fast. An historian who studied the beginning of the electrical lighting industry in the U.S. pointed out that in ten years, Thomas Edison moved from a maverick trying to get incandescent lighting accepted as feasible to a staunch opponent of the "dangerous" innovation of alternating current. H. Passer, The Electrical Manufacturers 1875-1900, at 174 (1953). The same phenomenon has been noted repeatedly. See, e.g., Scherer, Invention and Innovation in the Watt-Boulton Steam-Engine Venture, 6 Tech. & Culture 165, 174 (1965), quoting a letter from James Watt, inventor of the steam engine, to his partner James Boulton:

On the whole I find it is now full time to cease attempting to invent new things, or to attempt anything which is attended with any risk of not succeeding . . . . Let us go on executing the things we understand, and leave the rest to younger men, who have neither money nor character to lose.

See also M. Kamien & N. Schwartz, supra note 125, at 74-75 (examining alternative explanations of why innovators stop innovating).

n142 See R. Nelson & S. Winter, An Evolutionary Theory of Economic Change, passim (1982).

n143 See R. Nelson & S. Winter, supra note 142, at 389. To the extent that the holder of a broad patent has market power, it is relevant to note that analysts of monopoly power often remark on the monopolist's reduced incentives to innovate. See K. Arrow, Economic Welfare and the Allocation of Resources for Invention, in The Rate and Direction of Inventive Activity 609, 619-22 (R. Nelson ed. 1962) (concluding from model that monopolist's incentive to innovate is lower than inventor in competitive industry); M. Kamien & N. Schwartz, supra note 125, at 29-30:

The firm presently realizing monopoly profits may be less motivated to seek additional profits than one earning only normal profits. It may, in other words, be less hungry for additional profits than the firm without a monopoly position. Several reasons for this are possible. First, it may begin to regard additional leisure as superior to additional profits . . . . Second, it may become more concerned with protecting its current monopoly position than in acquiring a new one.

n144 Invention and innovation are notoriously uncertain activities. C. Freeman, The Economics of Industrial Innovation 148-50 (2d ed. 1982); E. Mansfield, J. Rapoport, J. Schnee, S. Wagner & M. Hamburger, Research and Innovation in the Modern Corporation 9-10 (1971).

n145 As discussed earlier, many improvements are patentable, a fact that demonstrates the independent inventive contribution necessary to make a significant improvement. See supra notes 96-99 and accompanying text. A study of the history of innovations in almost any field will show the key importance of improvement inventions. One good source of such studies is E. von Hippel, The Sources of Innovation 131-207 (1988) (innovation histories of ten industries). See, for example, von Hippel's description of innovations in scientific instruments, several of them patented. He describes the invention of the gas chromatograph, id. at 133-35; then details the improvements in temperature programming, id. at 135; capillary columns, id. at 135; silanization ("[a] major step forward"), id. at 136; argon ionization (patented), id. at 138; electron capture detector, id. at 139; flame ionization detector (patented), id. at 139; mass spectrograph linkage (patented), id. at 140; and process control interface, id. at 141. Likewise, von Hippel describes the invention of nuclear magnetic resonance (NMR) imaging, id. at 143, then describes fourteen major improvements, id. at 145-53. The same pattern holds true for all his innovation histories. Although von Hippel does not directly compare the difficulty -- hence cost -- of improvement inventions, it is clear from his descriptions that many of the improvements were significant technical achievements. Thus cost and difficulty can be inferred.

n146 See, e.g., F. Contractor, International Technology Licensing: Compensation, Costs, and Negotiation 104-05 (1981) (transaction costs averaged over $100,000 for licensing deals studied); D. Teece, The Multinational Corporation and the Resource Cost of International Technology Transfer 44 (1976) (transfer costs constituted over 19% of total project costs in international projects studied); E. von Hippel, supra note 145, at 48 (summarizing empirical studies finding generally low net returns from licensing). More subtle transaction costs, such as possible opportunistic behavior, are described in F. Bidault, Technology Pricing: From Principles to Strategy 126-27 (B. Page & P. Sherwood trans. 1989), and Teece, Profiting from Technological Innovation: Implications for Integration, Collaboration, Licensing and Public Policy, 15 Res. Pol'y 285, 294 (1986).

n147 In addition to the studies by Teece and Contractor cited supra note 146, this point is illustrated by the terms of a broad cross-licensing agreement between DuPont and Imperial Chemical Industries, Ltd., of Great Britain. The agreement provided for blanket licensing of all patents owned by the two companies (one of the reasons it was found to have masked a cartel, see infra note 338), but "there was a clause allowing either party to remove a 'major invention' from the agreement altogether, so that they could make special terms." 2 W. Reader, Imperial Chemical Industries: A History 52-53 (1975).

n148 Caves, Crockell & Killing, The Imperfect Market for Technology Licenses, 45 Oxford Bull. Econ. & Statistics 249,260-62 (1983). A group led by Edwin Mansfield of the University of Pennsylvania reached the same general conclusion after conducting a similar empirical study. See E. Mansfield, A. Romeo, D. Teece, S. Wagner & P. Brach, Technology Transfer, Productivity, and Economic Policy (1982).

n149 Kitch, supra note 12, at 273 (footnote omitted).

n150 Id. See 30 U.S.C. §§ 23, 36 (1988); Hubbard, Drafting Private Agreements Relating to Public Lands, 3 Nat. Resources & Env't 9, 10 (1988).

n151 See 30 U.S.C. §§ 23, 35; Comment, The General Mining Law and the Doctrine of Pedis Possessio: The Case for Congressional Action, 49 U. Chi. L. Rev. 1026, 1027 n.6 (1982).

n152 Before a claim can be filed under federal law, one must identify a mineral deposit. 30 U.S.C. § 23. See Thomas v. Morton, 408 F. Supp. 1361 (D. Ariz. 1976), aff'd sub nom. Thomas v. Andrus, 552 F.2d 871 (9th Cir. 1977) (per curiam).
n153 30 U.S.C. § 28.

n154 State law protection is carried out under the doctrine of pedis possessio. See Comment, supra note 151, at 1032-46. On the work requirement and the closely related requirement of actual occupancy under this doctrine, see id. at 1033-34. In his study on the evolution of property rights among prospectors during the California Gold Rush, John Umbeck observes that even the earliest contracts establishing such rights included limitations on claim size and minimum working requirements. J. Umbeck, A Theory of Property Rights With Application to the California Gold Rush 91-98 (1981).

n155 The literature on common fisheries suggests that a similar consideration influences the design and allocation of fishing rights. This literature details a number of formal and informal limitations on the scope of fishing rights that are either in effect or have been proposed. See Charles, Fishery Socioeconomics: A Survey, 64 Land Econ. 276, 279-80 (1988); see also Clark, Major & Mollett, The Development and Implementation of New Zealand's ITQ Management System, in Rights Based Fishing 117, 128 (P. Neher, R. Arnason & N. Mollett eds. 1989) (describing New Zealand fish stock management system, which solves common pool overfishing problem by granting to fishermen "Individual Transferable Quotas" (ITQs), limited in scope by the volume of past catches); Gardner, The Enterprise Allocation System in the Offshore Groundfish Sector in Atlantic Canada, in Rights Based Fishing, supra, at 293, 299, 319 (describing similar allocation system based on historical catches in Canadian fishing industry, which made "[t]he race for fish . . . a thing of the past").

n156 See, e.g., Coase, The Problem of Social Cost, 3 J.L. & Econ. 1 (1960); H. Demsetz, Toward a Theory of Property Rights, in 1 Organization of Economic Activity 104 (1988).

n157 See H. Demsetz, supra note 156, at 112-13 (discussion of bargaining using example of patents); see also Anderson, Conceptual Constructs for Practical ITQ Management Policies, in Rights Based Fishing, supra note 155, at 191, 196 (concluding that the market for randomly-allocated ITQs would lead to efficient allocation via trading among firms).

n158 See R. Cooter & T. Ulen, Law and Economics 105 n.15 (1988).

n159 Consider a numerical example. Suppose an inventor has expected profit of $1000 from a pioneering invention. An improver has developed a modification which the improver expects will bring profits of $400. But the improver's entry into the market will reduce the pioneer's profits by $300 because the improvement substitutes for some component in the pioneer's product, reduces the need for replacement parts or the like. If the pioneer's patent covers the improvement, the improver must take out a license. If this is known in advance, the pioneer will demand to be compensated out of the improver's profits for its $300 loss in profits. The improver's expected profit -- after paying a royalty to the pioneer under the license -- will be only $100. But if the pioneer's rights do not cover the improvement, the improver can market it without a license from the pioneer. Then the improver's expected profit will once again be $400. It is important to note two things about this example: first, it demonstrates the increased incentives for improvements when initial rights are narrow. But second, it also clearly demonstrates the cost of narrow scope -- a reduced incentive for the pioneer to innovate in the first place. (Note that with narrow rights, the pioneer's expected profits drop from $1000 to $700 after the improver enters without taking out a license.) In fact, taken to its logical conclusion, this is an argument for no patent rights at all, clearly the wrong result. Consequently it is important to restate one point: We are not advocating extremely narrow rights, designed to maximize the incentives to improve; we are arguing that, in close cases where scope doctrines are at issue, decision makers should opt for narrow scope to advance the important interests of society in encouraging improvements.

n160 In fact, it is the positive-sum aspects of allowing more competition for improvements that lead us to advocate narrowing the scope of the initial inventor's patent. In addition, of course, are the well-known problems of transaction costs; it seems whimsical to assume that all improvers and potential improvers will be able to bargain with the holders of pioneering patents. Imagine the magnitude of these costs: identifying all the prospective improvers; agreeing on the value of the pioneering invention and the expected value of the improvement; and finding an acceptable division of profits from the "surplus" created when the improvement is combined with the pioneer invention. For some background on the strategic aspects of licensing transactions, see F. Bidault, supra note 146, 83-137; see also Meurer, The Settlement of Patent Litigation, 20 Rand J. Econ. 77,77 (1989) ("patent validity disputes are not always resolved with licensing agreements because of incentive problems created by private information about validity"). For a heroic effort to imagine a world where these costs are manageable, see Yu, A Contractual Remedy to Premature Innovation: The Vertical Integration of Brand-Name Specific Research, 22 Econ. Inquiry 660 (1984) (arguing that (1) current property rights encourage "rushing" of innovation, and (2) a contractual solution exists whereby manufacturers form pre-invention contracts with prospective inventors). On the effect of multiple bargainers, see generally Cooter, Coase Theorem, in 1 The New Palgrave: A Dictionary of Economics 457, 458 (1987) (example of many farmers in Coase's famous farmer-railroad bargaining hypothetical). Without such bargaining the exchange mechanism on which the property rights literature relies so heavily cannot work. It is worth noting in this regard that even in the property rights-based fish harvest schemes described above, the scope of initial entitlements is carefully crafted. See, e.g., Gardner, supra note 155, at 298.

n161 For a general discussion, see Nelson, Capitalism as an Engine of Progress, Res. Pol'y (forthcoming).

n162 See, e.g., Griliches, Introduction, in R & D, Patents, and Productivity 1, 17 (Z. Griliches ed. 1984) (listing several problems concerning the ability to detect the major effects of research and development on productivity). One issue that is prior to these -- and that to some is still undecided -- is whether growth should be the goal of an economic system at all. See generally H. Arendt, The Rise and Fall of Economic Growth (1978) (intellectual history of the economic concepts of progress, growth, and development). For a summary of criticisms of growth, see id. at 84-97.

n163 See, e.g., Pakes & Griliches, Patents and R & D at the Firm Level: A First Look, in R & D, Patents & Productivity, supra note 162, at 55. Of course, one might argue that narrowing patent scope at the margin will redirect investment away from pioneering inventions and toward improvements on existing products. But two factors mitigate this. First, reducing scope at the margin will not completely eliminate the advantages of a pioneering invention over an improvement. Even without patents, pioneering inventions can lead to much higher returns than mere improvements. Second, narrower scope does not mean that pioneering inventions have only the scope of an improvement. There is still a good deal of difference between a narrower-at-the-margins pioneering patent and a mere improvement patent.

n164 See, e.g., F. Scherer, Innovation and Growth: Schumpeterian Perspectives 257-59, 270-85 (1984).

n165 A. Link & G. Tassey, Strategies for Technology-Based Competition 7 (1987); D. Jorgenson, Microeconomics and Productivity, in The Positive Sum Strategy: Harnessing Technology for Economic Growth 57, 57-76 (R. Landau & N. Rosenberg, eds. 1986); cf. H. Arendt, supra note 162, at 142-51 (describing the strong consensus in favor of economic growth).

n166 A noted economist who studied technical change made a related point. Machlup, The Optimum Lag of Imitation Behind Innovation, in Selected Economic Writings of Fritz Machlup 485, 502 (G. Bitros ed. 1976) (concluding that "longer imitation lags are uneconomical . . . , [but] no reliable clue has turned up as to the length of the optimum lag"). There has been some debate, however, over the question of the optimal timing of innovations and improvements. See, e.g., F. Scherer, supra note 164, at 67-82; Nelson, Uncertainty, Learning, and the Economics of Parallel Research and Development Efforts, 43 Rev. Econ. & Statistics 351 (1961). But note that this literature studies optimal timing from the point of view of the innovating firm; from society's point of view, there may be additional advantages to sooner rather than later.

n167 See 35 U.S.C. § 102(g) (1988).

n168 See 3 D. Chisum, supra note 45, § 10.03[1] (describing priority of invention rules, noting that first to reduce to practice is prima facie true inventor, and other inventors who wish to claim priority must prove earlier date of conception).

n169 See 35 U.S.C. § 102(b) (person entitled to patent unless, inter alia, invention was published, used or sold more than one year before application was filed).

n170 On cumulative industries, see R. Nelsond & S. Winter, supra note 142, at 255-62.

n171 See supra notes 25-29 and accompanying text.

n172 See J. Jewkes, D. Sawers & R. Stillerman, The Sources of Invention 234-35 (2d ed. 1969).

n173 See E. von Hippel, supra note 145, at 53 ("[T]he mechanisms by which pharmaceuticals achieve their medical effects are often not well understood. When this is so, potential imitators cannot gain much helpful insight from examining a competitor's patented product.").

n174 See, e.g., Graham v. John Deere Co., 383 U.S. 1, 26, 148 U.S.P.Q. (BNA) 459 (1966) (invalidating patent on spray pump bottle with hold-down cap); K. Brown, Inventors at Work; Interviews with 16 Notable American Inventors 366-68 (1988) (interview with Nat Wyeth, inventor of the plastic soda bottle).

n175 See, e.g., Moleculon Research Corp. v. CBS, Inc., 872 F.2d 407, 10 U.S.P.Q.2d (BNA) 1390 (Fed.Cir. 1989) (finding no infringement of patent on "Rubik's Cube").

n176 Ballpoint pens, for instance, involve basically a barrel, the point and ink. Note that even here, however, improvement inventions are possible -- just not very many of them, compared to cumulative technologies. See, e.g., J. Jewkes, D. Sawers & R. Stillerman, supra note 172, at 235 (describing invention of quick-drying ink by inventor unaffiliated with ballpoint pen inventors). Thus even ballpoint pens have some of the qualities of a cumulative technology -- demonstrating the difficulties of any classification scheme along this dimension. Nevertheless, overall, they must be characterized as a discrete technology.

n177 See R. Nelson & S. Winter, supra note 142, at 255-62; see also D. Sahal, Patterns of Technological Innovation 37 (1981) (describing cumulative nature of technical advance in aluminum products, electrical generation, petroleum refining and synthetic fiber production); Levin, Appropriability, R&D Spending, and Technological Performance, 78 Am. Econ. Rev. 424, 427 (1988) (contrasting chemical and drug industries prior to advances in genetic engineering -- which the author uses as examples of discrete technologies -- with "cumulative industries" such as electronics). It should be noted that at least one analyst of technical change sees all technical progress as the process of cumulative change. See D. Sahal, supra, at 112.

n178 See, e.g., S. Hollander, The Sources of Increased Efficiency: A Study of DuPont Rayon Plants 203-04 (1965) (concluding that "minor" improvements "accounted for over two-thirds of the unit-cost reductions attributable to technical change at most of the plants considered"); Enos, A Measure of the Rate of Technological Progress in the Petroleum Refining Industry, 6 J. Indus. Econ. 180, 187 (1958) (emphasizing the cumulative quantitative importance of small improvements in petroleum refining processes).

n179 A good description of the nature of invention can be found in the innovation histories of the industries studied by Eric von Hippel that we would classify as cumulative. See E. von Hippel, supra note 145, at 163-82 (semiconductors); id. at 188-95 (tractor shovels). The latter series of innovations are, of course, only one component in the overall composition of farm tractors. See D. Sahal, supra note 177, at 132-36.

n180 See, e.g., Dosi, Technological Paradigms and Technological Trajectories: A Suggested Interpretation of the Determinants and Directions of Technical Change, 11 Res. Pol'y 147 (1982).

n181 For example, the semiconductor industry supplies an essential component for electronics, automobiles and many other products. See T. Howell, et al., The Microelectronics Race 4-13 (1988).

n183 See supra notes 96-121 and accompanying text.

n184 See supra note 97 and accompanying text.

n182 See infra notes 191-222 and accompanying text.

n183 See supra notes 96-121 and accompanying text.

n184 See supra note 97 and accompanying text.

n185 C. Taylor & Z. Silberston, The Economic Impact of the Patent System: A Study of the British Experience 252 (1973) ("unpredictability [of the behavior of chemicals in the human body] is of a much higher order than that found in non-biological areas of chemical research -- and very much higher than that in engineering fields"); 2 D. Chisum, supra note 45, § 5.04[6], at 5-312 ("[A] newly-synthesized compound may be very similar in structure to known and existing compounds and yet exhibit very different properties."). Several of the rules governing chemical patents reflect the inability routinely to predict function given a certain chemical structure. See, e.g., In re Papesch, 315 F.2d 381, 386-89, 137 U.S.P.Q. (BNA) 43, 47-50 (C.C.P.A. 1963) (describing chemical obviousness doctrine whereby compound's structural similarity to prior art raises presumption that compound is obvious that can be overcome by evidence that claimed compound exhibits new and unexpected properties); In re Fisher, 427 F.2d 833, 839, 166 U.S.P.Q. (BNA) 18, 24 (C.C.P.A. 1970) ("In cases involving unpredictable factors, such as most chemical reactions and physiological activity, the scope of enablement obviously varies inversely with the degree of unpredictability of the factors involved."). On this latter point, see supra note 68 (discussion of Patent Office rules on enablement in various arts).

n186 See, e.g., D. Hounshell & J. Smith, Science and Corporate Strategy: DuPont R&D, 1902-1980, at 480-81 (1988) (describing applications of Du Pont's polyethylene in all segments of the plastics market); id. at 482-86, 708 n.42 (describing wide ranging applications for polytetrafluoroethylene, tradename Teflon).

n187 See R. Nelson & S. Winter, supra note 142, at 334-37; Dosi, supra note 180, at 148-49 (description of science-based industries using a different industry taxonomy).

n188 Other examples of science-based industries include medical diagnostic equipment (e.g., nuclear magnetic resonance), lasers, and the still nascent superconductor industry. See generally M. Kenney, Biotechnology: The University-Industrial Complex (1986); Kenney, Schumpeterian Innovative and Entrepreneurs in Capitalism: A Case Study of the U.S. Biotechnology Industry, 15 Res. Pol'y 21 (1986) (describing role of scientists, as well as entrepreneurs and capitalists).

n189 See, e.g., the description of the commercial development of diagnostic testing kits using monoclonal antibodies, infra notes 307-313 and accompanying text.

n190 In theory, the nonobviousness requirement of 35 U.S.C. § 103 (1988) will prevent such obvious inventions from receiving patents. In practice, for a variety of reasons, this requirement does not always function properly. See Merges, Commercial Success and Patent Standards: Economic Perspectives on Innovation, 76 Calif. L. Rev. 803, 857-58 (1988) (discussing invention of monoclonal antibody in critique of nonobviousness doctrine).

n191 H. Passer, supra note 141, at 152.

n192 Edison Elec. Light Co. v. United States Elec. Lighting Co., 47 F. 454 (C.C.S.D.N.Y. 1891), aff'd, 52 F. 300 (2d Cir. 1892).

n193 See A. Bright, The Electric-Lamp Industry: Technological Change and Economic Development from 1800 to 1947, at 89 (1949).

n194 Id. at 89. See United States v. General Elec. Co., 82 F. Supp. 753, 771, 80 U.S.P.Q. (BNA) 195, 205 (D.N.J. 1949) (describing Edison patents and their "virtual monopoly of the domestic supply in electric lamps" from 1891 to 1894, in finding defendant liable for various antitrust violations).

n195 A. Bright, supra note 193, at 91, 92 (Table XI). The patent expired in 1894 -- instead of 1897, seventeen years after issue -- because a Canadian counterpart patent expired in 1894, and thus (under then-existing law), so did the U.S. patent. See id. at 91.

n196 Id. at 93.

n197 Id.

n198 Id. at 108.

n199 Id. at 122.

n200 Id. at 122-23. See M. MacLaren, The Rise of the Electrical Industry During the Nineteenth Century 79 (1943) (describing corporate alliances in early electrical industry resulting from patent blockages); H. Passer, supra note 141, at 324-25 (describing extensive patent blockages leading to merger of Edison General Electric and the Thomson-Houston Company to form General Electric).

n201 A. Bright, supra note 193, at 138.

n202 Id. at 138-39. On General Electric's need to catch up technologically after the Edison patent expired in 1894, see T. Hughes, American Genesis: A Century of Invention and Technological Enthusiasm, 1870-1970, at 166-67 (1989). For a desciption of organizational complacency, and the "shocks" that can break a firm out of a comfortable torpor, see Cyert & March, Organizational Structure and Pricing Behavior in an Oligopolistic Market, 45 Am. Econ. Rev. 129 (1955) (firms with suddenly declining market shares strove more vigorously to increase their sales than firms whose shares were steady or increasing). In another paper, Cyert and March provided an explanation: firms are complacent "until some form of shock (such as failing to meet its goals) forces a kind of search behavior on the organization." Cyert & March, Organizational Factors in the Theory of Oligopoly, 70 Q.J. Econ. 44, 54 (1956).

n203 H. Passer, supra note 141, at 41.

n204 See Gramme Elec. Co. v. Arnoux & Hochhausen Elec. Co., 17 F. 838 (C.C.S.D.N.Y. 1883).

n205 H. Passer, supra note 141, at 41.

n206 See A. Bright, supra note 193, at 109; A. Marcus & H. Segal, Technology in America: A Brief History 144 (1989) ("Brush's initial success in manipulating dynamos, circuits, and arc lamps . . . engendered competition and yielded improvements" from several competitors).

n207 Arc lights work because an electrical current will jump a gap between certain conductors. This is a different principle from the incandescent lamp, which casts light because the current meets resistance in the filament, causing the filament to glow. Arc lights are brighter; this is why they have been extensively used in outdoor lighting, for instance.

n208 Brush Elec. Co. v. Western Elec. Co., 69 F. 240, 246 (C.C.N.D. Ill. 1895), aff'd, 76 F. 761 (7th Cir. 1896). Another case previously had held that the Brush patent had been infringed by he same device at issue in the Western Electric case, but Brush apparently was unwilling to litigate the patent for a third time because the later Western Electric decision is the last regarding this patent. See Brush Elec. Co. v. Western Elec. Light & Power Co., 43 F. 533 (C.C.N.D.) Ohio 1890).

n209 H. Passer, supra note 141, at 42. See M. MacLaren, supra note 200, at 70-71 (describing the many investigators who were attempting to make improvements to the basic arc light design); D. Noble, America By Design: Science, Technology and the Rise of Corporate Capitalism 7 (1977) ("Neither the arc lamp nor the dynamo proved patentable in court tests, however, and, as a result, the manufacture of arc-lighting systems became fiercely competitive.") The Brush Company actually tried to establish patent dominance over another segment of the industry -- the market for replacement lamp carbons. This effort failed when, in 1887, its patent on copper-coated carbons was held invalid; once again, the result was an industry that "strongly resembled the economist's conception of pure competition . . . . " Id. at 62.

n210 See supra notes 31-34 and accompanying text.

n211 See, e.g., Wright Co. v. Herring-Curtiss Co., 204 F. 597 (W.D.N.Y. 1913), aff'd 211 F. 654 (2d Cir. 1914); Wright Co. v. Paulhan, 177 F. 261 (C.C.S.D.N.Y.) (L. Hand, J.), rev'd, 180 F. 112 (2d Cir. 1910); W. Kaiser & C. Stonier, The Development of the Aerospace Industry on Long Island: Financial and Related Aspects 4-11 (Hofstra Univ. Yearbook of Business, Series 5, vol. 4 1968); supra notes 31-34 and accompanying text.

n212 See Dykman, Patent Licensing Within the Manufacturer's Aircraft Association (MAA), 46 J. Pat. Off. Soc'y 646, 647 (1964) (describing formation of industry licensing pool at behest of government because, "[n]o one would license the other under anything like a reasonable basis"). The Curtiss-Wright dispute was the centerpiece of a larger patent logjam in the early aircraft industry. See W. Kaiser & C. Stonier, supra note 211, at 4-11.

n213 One can argue that the broad Selden patent should not have been granted in the first place. His critics argued that Selden never built or operated the automobile that was pictured and described in the specification. Of course, this is not a prerequisite to obtaining a patent. See 3 D. Chisum, supra note 45, § 10.05[1] (describing doctrine of constructive reduction to practice whereby filing patent application can constitute sufficient reduction to practice to merit priority of invention). His critics argued further that in any event Selden's claims exceeded what the specifications enabled. Cf. Electric Vehicle Co. v. C.A. Duerr & Co., 172 F. 923, 926 (C.C.S.D.N.Y. 1909), rev'd sub nom. Columbia Motor Car Co. v. C.A. Duerr & Co., 184 F. 893 (2d Cir. 1911); Electric Vehicle Co. v. Winton Motor-Carriage Co., 104 F. 814, 816 (C.C.S.D.N.Y. 1900). See generally J. Flink, America Adopts the Automobile, 1895-1910, at 318-19 (1970) (describing Selden's assignment of patent to the Electric Vehicle Company, whose motive was probably "to hedge against the possibility that the gasoline automobile might prove superior" to the electric vehicle being developed by the company).

n214 If they had used the patent for this purpose, we would expect to see a record of licensing agreements whereby firms specializing in various aspects of the automobile were given licenses and in turn were required to contribute or license their improvements back to Selden and his assignee. No such agreements seem to have been made, despite rapid progress in various aspects of automobile design. Cf. D. Hounshell, From the American System to Mass Production, 1800-1932: The Development of Manufacturing Technology in the United States 274 (1984) (describing Ford's improvements in engines, electric starters, flywheels, etc.).

n215 In 1903, several years after the Selden patent survived its first challenge, Winton Motor-Carriage Co., 104 F. at 816, the Association of Licensed Automobile Manufacturers (ALAM) was formed. Until it was dissolved in 1911, following the first case finding that the Selden patent had not been infringed, the ALAM exercised some measure of control over the automobile industry through its power to deny licenses to new companies. See J. Flink, supra note 213, at 321.

  n216 Id. Although controlling competition for improvements might be a part of an orderly development strategy, there is no evidence that the association was doing anything to develop the Selden "prospect." Thus its efforts to control competition look like naked restrictions on entry, not part of a coordinated development scheme.

n217 One historian of the industry states: That consumers were in some cases actually intimidated from buying the products of perfectly "good and reliable" but unlicensed manufacturers is . . . quite probable; certainly the advertisements of the A.L.A.M. attempted to accomplish this result. In response to the association's repeated warning "Do Not Buy a Lawsuit with Your Automobile," the Ford Company offered to give each purchaser a bond protecting him against any damages that might arise from this quarter.

R. Epstein, The Automobile Industry 233 (1928). As to Ford, the Selden patent did not stop him, but it did slow him down. See J. Flink, supra note 213, at 323-27 (describing Henry Ford's battle against the Selden patent).

n218 See Columbia Motor Car Co. v. C.A. Duerr & Co., 184 F. 893, 908-09 (2d Cir. 1911).

n219 See Wright Co. v. Paulhan, 177 F. 261, 271 (C.C.S.D.N.Y.) (L. Hand, J.), rev'd, 180 F. 112 (2d Cir. 1910); Zollmann, Patent Rights in Aircraft, 11 Marq. L. Rev. 216, 218-19 (1927).

n220 See Wright Co. v. Herring-Curtiss Co., 204 F. 597, 614 (W.D.N.Y. 1913) (finding that defendants' admittedly different design infringed plaintiff's broad pioneer patent on airplane stabilization), aff'd 211 F. 654 (2d Cir. 1914).

n221 See Bittlingmayer, Property Rights, Progress, and the Aircraft Patent Agreement, 31 J.L. & Econ. 227, 232 (1988).

n222 See W. Kaiser & C. Stonier, supra note 211, at 4-11; Bittlingmayer, supra note 221, at 236-40.

n223 See S. Sturmey, The Economic Development of Radio 16 (1958); H. Aitken, Syntony and Spark: The Origins of Radio 203-05 (1976).

n224 W. MacLaurin, Invention and Innovation in the Radio Industry 45 (1949) (acquisition of basic patent by Lodge on tuning, and issuance of major improvement patent to Marconi, the famous British 7777 patent and American equivalent, filed in 1900).

n225 Sturmey cites "a reliable opinion" as describing the Lodge tuning patent, acquired by Marconi, as "a master patent, or something very like it." S. Sturmey, supra note 223, at 17. Marconi's rights in the Fleming "valve" (vacuum tube) patent -- said to be basic to the whole art -- dated to its invention in 1904. See id. at 32.

n226 AT&T entered the radio field when it became concerned that radio could become a possible competitor to its long distance telephone line technology.

n227 See L. Reich, The Making of American Industrial Research: Science and Business at GE and Bell, 1876-1926 (1985) (triode invented by Lee De Forest). The history of the vitriolic interference between De Forest and Edwin Armstrong, who claimed priority of invention,is summarized in Radio Corp. of Am. v. Radio Eng'g Laboratories, 293 U.S. 1, 2-7 (1934). Many believed then, and still believe, that De Forest was wrongly given priority. See G. Douglas, The Early Days of Radio Broadcasting 12 (1987); McCormack, The Regenerative Circuit Litigation, 5 Air L. Rev. 282, 293-95 (1934).

n228 See G. Douglas, supra note 227, at 8.

n229 See W. MacLaurin, supra note 224, at 94.

n230 See G. Douglas, supra note 227, at 19-20.

n231 See Federal Trade Comm'n, Report of the Federal Trade Commission on the Radio Industry in Response to House Resolution 548, 67th Cong., 4th Sess., Dec. 1, 1923, at 27 (1924) [hereinafter FTC Report].

n232 Marconi Wireless Tel. Co. of Am. v. De Forest Radio Tel. & Tel. Co., 236 F. 942, 955 (S.D.N.Y. 1916), aff'd, 243 F. 560, 566-67 (2d Cir. 1917).

n233 See FTC Report, supra note 231, at 26.

n234 See supra notes 96-127 and accompanying text. De Forest's improvement was considered a major technical advance. Hugh Aitken stated the the invention of the triode "is one of the 'great divides' in the history of radio technology; the whole basis of radio communication begins to shift with the introduction and diffusion of this device." H. Aitken, The Continuous Wave: Technology and American Radio, 1900-1932, at 195 (1985) [hereinafter The Continuous Wave].

n235 This was the aborted attempt by Marconi to acquire General Electric's alternator technology, as embodied in the Alexanderson patent. This is perhaps anomalous, however, as General Electric might well have agreed to the transaction except for an appeal by the American military to keep this sensitive technology in the hands of domestic interests. See FTC Report, supra note 231, at 14-16. The U.S. Navy ultimately facilitated the formation of RCA, which broke the patent impasse. See infra notes 237-240 and accompanying text.

n236 See FTC Report, supra note 231, at 25:

The Navy, in a patent investigation in 1919, had "found that there was not a single company among those making radio sets for the Navy which possessed basic patents sufficient to enable them to supply, without infringement, . . . a complete transmitter or receiver."

(Citation omitted.)

n237 See The Continuous Wave, supra note 234, at 249 (impetus behind formation of RCA was that patent rights "threatened to impede further development and commercial exploitation"); S. Sturmey, supra note 223, at 275 (broad patents retarded growth of radio industry).

n238 General Electric, "[s]timulated by the Navy," actually formed the Radio Corporation of America (RCA) in 1919. W. MacLaurin, supra note 224, at 103; FTC Report, supra note 231, at 18-21.

n239 See FTC Report, supra note 231, at 20-21. RCA also entered into a cross-licensing agreement with General Electric. Id. at 21-22.

 
n240 RCA used package licenses coupled with high royalties to maintain its dominant position. See M. Graham, RCA and the VideoDisc: The Business of Research 41 (1986). Graham describes RCA's use of package licensing to dominate the radio industry from the 1920s until the antitrust enforcement actions of 1958:

Perhaps the most important enduring consequence of the policy was that it made it uneconomic for most other companies to do radio-related research, because they could not recoup their investment. This left control of the rate and direction of technological change in the radio industry largely in the hands of RCA.

Id.

 n241 See United States v. Western Elec. Co., 1956 Trade Cas. (CCH) P68,246, at 71,137-138 (D.N.J. 1956).

n242 See Levin, supra note 86.

n243 Id. at 76.

n244 Id. at 80; J. Tilton, supra note 86, at 77.

n245 Levin, supra note 86, at 78.

n246 See N. Stern, From ENIAC to UNIVAC: An Appraisal of the Eckert-Mauchly Computers 2-4 (1981) (citing Honeywell, Inc. v. Sperry-Rand Corp., No. 4-67 Civ. 138 (Minn. Oct. 19, 1973)).

n247 See C. Taylor & Z. Silbertson, supra note 185, at 294-95.

n248 See generally K. Flamm, Targeting the Computer: Government Support and International Competition (1987).

n249 Cf. H. Aitken, supra note 223, at 308 (describing the development of the American radio industry as "speculative and erratic"); id. at 330 (describing lack of specialization in early days of radio development); id. at 333 (describing the early days of radio when the interactions between scientific, technological, and economic aspects of radio "were only dimly perceived and when institutions to cope with them had barely begun to evolve"). Hugh Aitken describes the progress from the early scientific work of Hertz to Fleming's diode as "highly empirical in nature, very much a matter of trial and error." Id. at 303.

n250 For example, the Patent Office interference action concerning the triode originally involved four inventors, two of whom -- Edwin H. Armstrong and Irving Langmuir of General Electric -- filed patent applications on the same day, October 29, 1913. See McCormack, supra note 227, at 282. And in 1915 Alexanderson's alternator became available for the first time. H. Aitken, supra note 223, at 281; W. MacLaurin, supra note 224, at 94. At the same time, AT&T was pioneering research in vacuum tubes. W. MacLaurin, supra note 224, at 95-96.

n251 Valuation problems in licensing transactions are difficult enough after an invention has been made; they would seem to be inconceivably difficult prior to invention. Cf. Meurer, supra note 160, at 80-84 (pointing out that patent validity disputes are not always resolved with licensing agreements because of asymmetric information about validity). It is therefore quite believable that ex ante coordination efforts would quickly break down since prospective inventors would likely value their future improvements more highly than the coordinating firm.

n252 See The Continuous Wave, supra note 234, at 389 n.5. Westinghouse is perhaps another plausible candidate; by acquiring rights to Armstrong's "regenerative circuit" (triode) patent, see W. MacLaurin, supra note 224, at 106, and an important signal generation patent, they had what appeared to be an infringement-free transmission system, but would have needed some rights to make vacuum tubes. The Continuous Wave, supra note 234, at 476-77.

n253 Work by Irving Langmuir of General Electric, an original party to the four-way interference over the triode, might have established some rights in this field. Cf. The Continuous Wave, supra note 234, at 231 (Langmuir's early work on triode amplification produced results superior to DE Forest's); id. at 248 (Langmuir part of original interference).

n254 GE almost acquired Armstrong's rights during the pendency of the interference, but he eventually sold them to Westinghouse. See W. MacLaurin, supra note 224, at 106.

n255 This is analogous to the strategic problem discussed earlier in the context of bargaining between the holder of a basic patent and the inventor of a very major improvement. See supra notes 115-120 and accompanying text.

n256 Note too that the savings in transaction costs accompanying consolidation must be weighed against the potential anticompetitive effects of the unified firm. See generally O. Williamson, Markets and Hierarchies: Analysis and Antitrust Implications 155-233 (1975).

n257 See supra notes 221-237 and accompanying text.

n258 See supra notes 194-196, 199 and accompanying text.

n259 David Landes, the noted historian of technology, has called the business of chemical manufacture "the most miscellaneous of industries." D. Landes, The Unbound Prometheus: Technological Change and Industrial Development in Western Europe from 1750 to the Present 269 (1969).

n260 See infra notes 171-180 and accompanying text; cf. Levin, supra note 177, at 427 (chemical and drug industries are discrete technology areas "in which innovations . . . stand alone as isolated discoveries").

n261 Most chemical claims cover a single compound only in the sense that Gillette's claim covered a single type of razor. That is, chemical claims routinely embrace minor variations on the basic structure the inventor discovered. For example, a patentee might claim a compound of structure "Atom 1-Atom 2- Sidegroup," where "Sidegroup" is defined in the claim as including either "N-O-O-H" or "N-H2." See Ex parte Markush, 1925 Dec. Comm'r Pats. 126, 128, 340 Off. Gazz. Pat. Off. 839 (1924); 2 D. Chisum, supra note 45, § 8.06[2]. The "family" of variations must share a common principle to be patented using a so-called Markush claim; as stated in In re Schechter, 205 F.2d 185, 189, 98 U.S.P.Q. (BNA) 144, 149 (C.C.P.A. 1953), such a claim will be allowed "where the substances grouped have a community of chemical and physical characteristics which justify their inclusion in a common group, and such inclusion is not repugnant to the principles of scientific classification." Id. (citations omitted).

n262 Obviousness and enablement rules for chemical inventions reflect the accepted unpredictability of chemical inventions. See supra notes 194-197 and accompanying text; see also In re Bundy, 642 F.2d 430, 434, 209 U.S.P.Q. (BNA) 48, 51 (C.C.P.A. 1981) (finding sufficient support for patent specification despite absence of precise description of behavior of all analogs of compound); Studiengesellschaft Kohle mbH v. Eastman Kodak Co., 616 F.2d 1315, 1341, 206 U.S.P.Q. (BNA) 577, 600 (5th Cir.) ("[I]n catalytic chemistry, minor changes in components, their ratio, or the external condition of the reaction may produce major changes in the reaction itself."), cert. denied, 449 U.S. 1014, 208 U.S.P.Q. (BNA) 88 (1980).

n263 See C. Taylor & Z. Silberston, supra note 185, at 244-45; see also E. von Hippel, supra note 145, at 66-67 (describing unusual strength of patents in pharmaceutical and chemical industries relative to other industries).

n264 C. Taylor & Z. Silberston, supra note 185, at 268: The range of [bulk] products has not widened very much over half a century, although naturally their relative importance has greatly changed. Most research efforts are directed towards the reduction of unit costs and improvements in the purity and consistency of standard products. There is relatively little work on new products . . . .

n265 See, e.g., infra notes 268-271 and accompanying text (example of alkali process inventions).

n266 See, e.g., infra note 272 and accompanying text. This is a function of the unpredictability of chemical inventions. For example, enablement doctrine requires greater support for a broad chemical claim than for a broad mechanical claim. See supra notes 38 and 180-181 and accompanying text. On the other hand, this same feature of chemical inventions makes it easier to establish nonobviousness. See, e.g., In re Papesch, 315 F.2d 381, 391-92, 137 U.S.P.Q. (BNA) 43, 51-52 (C.C.P.A. 1963) (even close structural similarity to the prior art may be overcome by evidence that the claimed compound exhibits new and unexpected properties). Thus, chemical patents are easier to obtain, but narrower in scope.

n267 C. Taylor & Z. Silberston, supra note 185, at 271-72; D. Hounshell & J. Smith, supra note 186, at 145, 174, 206, 439, 465, 494, 545 (describing widespread licensing of various Dupont Patents).

n268 See C. Freeman, supra note 144, at 28-29; D. Landes, supra note 259, at 111.

n269 C. Freeman, supra note 144, at 28-29.

n270 J. Jewkes, D. Sawers & R. Stillerman, supra note 172, at 50.

n271 On the improvement patent of 1873, see J. Jewkes, D. Sawers & R. Stillerman, supra note 172, at 50; Solvay Process Co. v. Michigan Alkali Co., 90 F. 818 (6th Cir. 1898). On the American licensee, see D. Noble, supra note 209, at 14.

n272 Christopher Freeman has described how the pattern of rather liberal cross licensing in chemical industries led to the development of a separate industry of chemical plant construction firms:

Technological progress in established basic industrial chemicals is so rapid and so internationalised that more is usually to be gained for both the firm and the country if each national process innovation is exploited by licensing the contracting industry and selling know-how.

Freeman, Chemical Process Plant: Innovation and the World Market, 45 Nat'l Inst. Econ. Rev. 29, 50 (1968).

n273 Standard Oil Co. v. American Cyanamid Co., 774 F.2d 448, 450 227 U.S.P.Q. (BNA) 293, 294 (Fed. Cir. 1985).

n274 See id. at 450-51, 227 U.S.P.Q. at 294-95.

n275 Id. at 450, 227 U.S.P.Q. at 294 (Standard Oil patent); id. at 451, 227 U.S.P.Q. at 295 (American Cyanamid patent); Dow Chem. Co. v. American Cyanamid Co., 816 F.2d 617, 617, 2 U.S.P.Q.2d (BNA) 1350, 1350 (Fed. Cir.) (Dow patent), cert. denied, 484 U.S. 849 (1987).

n276 See Standard Oil, 774 F.2d at 453, 227 U.S.P.Q. at 296.

n277 See Dow Chemical, 816 F.2d at 617, 2 U.S.P.Q.2d at 1350.

n278 None of the patents at issue in the various suits appear broad enough to serve the "prospect" function. Under the cases, for example, the Standard Oil process does not appear to infringe Dow's patents. Thus an independent route to the acrylamide-producing process is left open.

n279 The original Solvay alkali patent was of this nature; see supra notes 268-271 and accompanying text.

n280 Catalytic research led to the invention of polypropylene, for example. See infra note 294 and accompanying text.

n281 See, e.g., Standard Oil Co. v. American Cyanamid Co., 774 F.2d 448, 450, 227 U.S.P.Q. 293, 294 (Fed. Cir. 1985) (listing licensees of acrylamide production process patent); id. at 451, 227 U.S.P.Q. at 295 ("[Standard Oil] offered Cyanamid a license . . . [but] Cyanamid took the position that it did not need a license . . . .").

n282 See Mueller, The Origins of the Basic Inventions Underlying DuPont's Major Product and Process Inventions, 1920 to 1950, in The Rate and Direction of Inventive Activity, supra note 143, at 326.

n283 See id. at 328.

n284 See C. Freeman, supra note 144, at 61; see also S. Hollander, supra note 178, at 52-120, 199-200 (detailed study of major and minor process improvements at various DuPont rayon plants).

n285 2 W. Reader, supra note 147, at 52-53. Du Pont researchers first synthesized nylon in the late 1930s. The company obtained a series of broad product patents, C. Taylor & Z. Silberston, supra note 185, at 342, culminating with the "Nylon 66" patent covering a commercially valuable form of the fiber. See O'Brien, Patent Protection and Competition in Polyamide and Polyester Fibre Manufacture, 12 J. Indus. Econ. 224, 225 (1964).

n286 See D. Hounshell & J. Smith, supra note 186, at 384-86.

n287 Id. at 420-22.

n288 See J. Jewkes, D. Sawers & R. Stillerman, supra note 172, at 341-42. In the early 1950s, researchers at Phillips Petroleum were working on the same problem. Id. at 342.

n289 The original patent contained limitations relating to temperature, pressure and oxygen concentration. In fact one historian of the industry suggests that the search for high-density polyethylene may have been motivated in part by a desire to skirt the Imperial patents. J. Allen, Studies in Innovation in the Steel and Chemical Industries 47 (1967) ("Many of the early would-be Ziegler licensees . . . were, however, probably seeking a route free from the I.C.I. patents, either because they wished to be free, or could not get the know-how as well as the patents."). See Standard Oil Co. v. Montedison, 494 F. Supp. 370, 374-75, 206 U.S.P.Q. (BNA) 676, 685-87, 207 U.S.P.Q. (BNA) 298 (D. Del. 1980), aff'd, 664 F.2d 356, 212 U.S.P.Q. (BNA) 327 (3d Cir. 1981), cert. denied, 456 U.S. 915 (1982).

n290 C. Freeman, supra note 144, at 67; Montedison, 494 F. Supp. at 374-75, 206 U.S.P.Q. at 685-86. Polypropylene has emerged as a substitute for polyethylene in several key applications. See Smoluk, Poyolefin Foams Take More Performance Jobs, Modern Plastics, Feb. 1988, at 98-100; Mansfield, Nonwovens Report, Textile World, May 1987, at 12.

n291 See Montedison, 494 F. Supp. at 374, 206 U.S.P.Q. at 685 (patent interference between four firms). The fifth firm apparently bowed out of the competition. See id. at 374 n.4, 206 U.S.P.Q. at 685 n.4.

n292 The interference just mentioned, for example, was declared in 1958 and resolved by the District Court only in 1980. See also United States Steel Corp. v. Phillips Petroleum Co., 865 F.2d 1247, 1248, 9 U.S.P.Q.2d (BNA) 1461, 1462 (Fed. Cir. 1989) (upholding Phillips' polypropylene product patent).

n293 Polyethylene was discovered in 1935-36 by scientists from Imperial Chemical Industries of Great Britain; Imperial held the early product patents. 2 W. Reader, supra note 147, at 351-54; id. at 357 ("In the USA, the most important market, ICI held a 'composition of matter' patent which protected polythene [i.e., polyethylene] itself, regardless of the process by which it was made."); J. Allen, supra note 289, at 24-25; J. Jewkes, D. Sawers & R. Stillerman, supra note 172, at 280. Du Pont, however, held a patent on a commercially valuable form of the polyethylene. See O'Brien, supra note 285, at 229; C. Taylor & Z. Silberston, supra note 185, at 342. As part of a general cross-licensing and market-sharing arrangement, the two companies licensed these valuable patents to one another for production in their respective home markets. See 2 W. Reader, supra note 147, at 52-53.

This arrangement was challenged by United States antitrust authorities in the late 1940s and early 1950s. Id. at 428-44. The resulting consent decree ordered Du Pont and Imperial to license all patents covered by their agreements, including those remaining on nylon and polyethylene. See United States v. Imperial Chem. Indus., 105 F. Supp. 215, 93 U.S.P.Q. (BNA) 360 (S.D.N.Y. 1952). The compulsory licensing of polyethylene was ordered id. at 223. A follow-up study in Congress concluded that

the judgment appears to have made it possible for a substantial number of companies to enter this field. There appears to be substantially more competition in the manufacture and sale of polythene products than there was before the judgment was entered.

Staff of the Subcommittee on Patents, Trademarks, and Copyrights of the Senate Comm. on the Judiciary, supra note 7, at 13 (showing the Imperial had issued nine licenses on polyethylene by 1955; Du Pont had issued 17 for polyethylene and 40 for nylon); see also The Polyethylene Gamble, Fortune, Feb. 1954, at 134, 136 (describing eight firms competing in this field under licensing agreements). It is possible that Imperial would have licensed competitors in exchange for new process research, which its competitors pursued party to gain leverage in licensing negotiations. See 2 W. Reader, supra note 147, at 357 (Imperial was fortunate to have a United States product patent "because in Union Carbide, unknown to ICI, work was going on to develop a process entirely independent of ICI's, and it succeeded."); id. at 433 (describing DuPont's strategy of pursuing process-oriented research to lower the royalty Imperial could charge on polyethylene); see also United States v. Studiengesellschaft Kohle, m.b.H., 670 F.2d 1122, 1124, 212 U.S.P.Q. (BNA) 889, 891-92 (D.C. Cir. 1981) (describing Ziegler's exclusive license to make and sell catalysts to Hercules Incorporated, as well as his licensing of several others to use those catalysts in in-house production).

n294 245 F.2d 693, 113 U.S.P.Q. (BNA) 423 (4th Cir. 1957); see supra notes 53-55 and accompanying text.

n295 Id.; see also 1 D. Chisum, supra note 45, § 1.03[8][c] (collecting other cases on this point).

n296 See P. Grubb, Patents for Chemists 158 (1982); Marshall, Penn Charges Retin-A Inventor with Conflict, 247 Sci. 1028 (1990) (dispute between University of Pennsylvania and scientist over scientist's attempt to obtain a "new use" patent for Retin-A as a wrinkle reducer).

n297 Hand held that the purified adrenalin, although it existed in the human body, was transformed by the inventor's purification process into a useful drug and therefore constituted "for every practical purpose a new thing commercially and therapeutically." Parke-Davis & Co. v. H.K. Mulford & Co., 189 F. 95, 103 (C.C.S.D.N.Y. 1911) (L. Hand, J.), aff'd in part and rev'd in part, 196 F. 496 (2d Cir. 1912).

n298 See Scripps Clinic & Research Found. v. Genentech, Inc., 666 F. Supp. 1379, 1390, 3 U.S.P.Q.2d (BNA) 1481, 1488 (N.D. Cal. 1987), patent invalidated in Scripps Clinic & Research Found. v. Genentech, Inc., 707 F. Supp. 1547, 11 U.S.P.Q.2d (BNA) 1187 (N.D. Cal. 1989).

n299 See id.

n300 Scripps Clinic & Research Found., 707 F. Supp. at 1552, 11 U.S.P.Q.2d at 1191.

n301 See, e.g., Sit, Biotech, Amgen Remain at Odds, Boston Globe, Apr. 18, 1990, at 41, cols. 3, 3-5 (successful effort of Amgen to stay cross-licensing ordered by district court after both parties were found to infringe each other's patents on erythropoietin (EPO)).

n302 See supra note 12 and accompanying text.

n303 See supra notes 187-188 and accompanying text.

n304 See M. Kenney, supra note 188; Kenney, supra note 188. But cf. Koenig, A Bibliometric Analysis of Pharmaceutical Research, 12 Res. Pol'y 15, 35 (1983) (reviewing data on the number of industrial patents that cite basic scientific research articles in various pharmaceutical industry sectors, including biotechnology-derived pharmaceuticals, and concluding that industrial research feeds basic science in this field).

n305 At least in its earliest stages. See Nelson, The Link Between Science and Invention: The Case of the Transistor, in The Rate and Direction of Inventive Activity: Economic and Social Factors, supra note 143, at 549; Shockley, The Path to the Conception of the Junction Transistor, 23 IEEE Trans. on Electron Devices 597 (1976).

n306 Advances in Conductor Materials, N.Y. Times, Sept. 30, 1989, at 32, col. 1; Pool, Superconductor Patents: Four Groups Duke It Out, 245 Sci. 931 (1989).

n307 See Kohler & Milstein, Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity, 256 Nature 495, 495-97 (1975).

n308 Three Immunology Investigators Win Nobel Prize in Medicine, N.Y. Times, Oct. 16, 1984, at A1, col. 4.

n309 In fact, the last sentence of the Kohler-Milstein paper itself noted these possibilities. See Kohler & Milstein, supra note 307, at 497; see also Mackenzie, Cambrosio & Keating, The Commercial Application of a Scientific Discovery: The Case of the Hybridoma Technique, 17 Res. Pol'y 155 (1988).

n310 This discussion is taken from a longer account of the case in Merges, supra note 190, at 857-58.

n311 Hybritech, Inc. v. Monoclonal Antibodies, Inc., 623 F. Supp. 1344, 1353, 227 U.S.P.Q. (BNA) 215, 221 (N.D. Cal. 1985), rev'd 802 F.2d 1367, 231 U.S.P.Q. (BNA) 81 (Fed. Cir. 1986), cert. denied, 480 U.S. 947 (1987).

n312 See Cohen, et al., Construction of Biologically Functional Bacterial Plasmids In Vitro, 70 Proc. Nat'l Acad. Sci. 3240 (1973).

n313 The prosecution and licensing of this patent are ably described in Ku, Licensing DNA Cloning Technology, 23 LES Nouvelles 112 (June 1983). On the licensing of this patent, see M. Kenney, supra note 188.

n314 See U.S. Patent No. 4,704,362, issued Nov. 3, 1987.

n315 See S. Hall, Invisible Frontiers: The Race to Synthesize a Human Gene 317 (1987).

316 Id. at 152-53.

n319 See Genentech Receives Broad Patent For Basic Gene-Splicing Techniques, Wall St. J., Nov. 4, 1987, at 8, col. 1 (quoting George B. Rathman, Chairman and Chief Executive Officer of Amgen, Inc.). There are some indiiications that Genentech is pursuing a strategy of construng the patent claims broadly, but charging a fairly low royalty so as not to create an incentive to challenge the patent. See G-tech to Push for Royalties, BioEngineering News, Nov. 12, 1987, at 1, col. 1.

n320 In re O'Farrell, 853 F.2d 894, 7 U.S.P.Q.2d (BNA) 1673 (Fed. Cir. 1988).

n321 Id. at 899-901, 7 U.S.P.Q.2d at 1677-78. The frog protein was not truly nonoperational; it formed part of the structure of ribosomes, the cell components where proteins are made. This relatively rare type of ribosomal protein is to be contrasted with the much more common proteins coded for in a cell's DNA -- everything from hormones to collagen to antibodies. See id. at 897-98, 7 U.S.).Q.2d at 1676.

n322 Id. at 895, 7 U.S.P.Q.2d at 1674.

n323 See Pool, supra not 306 (organizations fighting over superconductivity patents).